HLA-A*1101 & B2M & KRASG12S (VVVGASGVGK)

HLA-A*1101 & B2M & KRASG12S (VVVGASGVGK) Liste de produits

Attribut
Protein (1)
Bibliothèque de produits
En ligne (1)
Espèces
Human (1)
Étiquette
His Tag & Avi Tag (1)
Marqueur
Biotin-labeled (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Structure protéique	Pureté	Caractéristiques	Pré-commande/Commande
HLS-H82E8	Human	HEK293	Biotinylated Human HLA-A*11:01&B2M&KRASG12S (VVVGASGVGK) Complex Protein (Monomer, MALS verified)				Ajouter au panier

Quantité totale1

HLA-A*1101 & B2M & KRASG12S (VVVGASGVGK)Contexte de la molécule

The peptide VVVGASGVGK, derived from the KRAS G12S mutation and presented by the HLA-A*11:01/β2-microglobulin (β2m) complex, is a pivotal antigenic target in antitumor immunity. This complex plays a crucial role by activating specific cytotoxic T lymphocytes (CTLs), enabling the immune system to recognize and eliminate tumor cells harboring the KRAS G12S mutation.

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
Paltusotine	CRN-00808	Phase 3 Clinical	Crinetics Pharmaceuticals Inc	Acromegaly; Malignant Carcinoid Syndrome; Neuroendocrine Tumors	Details
Lutetium-177 labelled edotreotide	ITM-11	Phase 3 Clinical	Universitaetsspitals Basel, Itm Solucin Gmbh	Solid tumours; Pancreatic neuroendocrine tumors (pNET); Neuroendocrine Tumors; Central Nervous System Neoplasms; Thymus Neoplasms; Lung Neoplasms; Lymphoma; Carcinoma, Neuroendocrine	Details
RYZ-101	RYZ-101	Phase 3 Clinical		Carcinoid Tumor; Stomach Neoplasms; Pancreatic neuroendocrine tumors (pNET); Small Cell Lung Carcinoma; Neuroendocrine Tumors; Carcinoma, Neuroendocrine; Gastrointestinal Neoplasms	Details
Gallium-68 satoreotide	68Ga-OPS-202; 68Ga IPN-1070; 68Ga-DOTA-JR11	Phase 2 Clinical	Ipsen Inc	Stomach Neoplasms; Pancreatic neuroendocrine tumors (pNET); Small Cell Lung Carcinoma; Breast Neoplasms; Gastrointestinal Neoplasms	Details
Nendratareotide uzatansine	BTP-277; PEN-221	Phase 2 Clinical	Tarveda Therapeutics Inc	Small Cell Lung Carcinoma; Neuroendocrine Tumors; Carcinoma, Neuroendocrine	Details
Yttrium 90-labelled edotreotide	SMT-487-[90Y]; DOTATOC-[90Y]	Phase 2 Clinical	The University Of Iowa, Novartis Pharma Ag	Central Nervous System Neoplasms; Meningioma; Melanoma; Lymphoma; Lung Neoplasms; Sarcoma; Neuroblastoma; Breast Neoplasms; Brain Neoplasms; Solid tumours; Neuroendocrine Tumors; Small Cell Lung Carcinoma; Adenoma, Islet Cell; Neoplasms; Pheochromocytoma; Carcinoid Tumor; Medulloblastoma	Details
Dopastatin	TBR-760; BIM-23A760	Phase 2 Clinical	Ipsen	Acromegaly; Malignant Carcinoid Syndrome; Adenoma; Pituitary Neoplasms	Details
ZT-01	ZT 01; ZT-01	Phase 2 Clinical	Tulane University, York University, University Of Toronto, Toronto	Diabetes Mellitus, Type 1; Hypoglycemia	Details
Re-188 P 2045	P2045; BAY-865284; Rhenium-188 P2045; Re-188 P 2045; Rh-188 P2045; Rhenium-188-P-2045	Phase 2 Clinical	Bayer AG	Neoplasm Recurrence, Local; Small Cell Lung Carcinoma; Neuroendocrine Tumors; Lung Neoplasms; Carcinoma, Small Cell; Carcinoma, Non-Small-Cell Lung	Details
[203-Pb] VMT-NET	[203-Pb] VMT-NET	Phase 2 Clinical	Perspective Therapeutics Inc	Head and Neck Neoplasms; Pheochromocytoma; Carcinoma, Renal Cell; Small Cell Lung Carcinoma; Neuroendocrine Tumors; Paraganglioma	Details
64Cu-SarTate		Phase 2 Clinical	University Of Melbourne	Neuroendocrine Tumors; Neuroblastoma; Meningioma	Details
Lutetium-177 DOTA satoreotide	[177Lu]LuSSO110; 177Lu-IPN-1072; OPS-201; 177Lu-IPN01072; 177LU-OPS 201; 177Lu-DOTA- JR11; 177Lu-satoreotide	Phase 1 Clinical	Ipsen, OctreoPharm Sciences GmbH	Small Cell Lung Carcinoma; Breast Neoplasms; Meningioma	Details
CRN-01941	CRN-01941	Phase 1 Clinical	Crinetics Pharmaceuticals Inc		Details
68Ga-NOTA-3PTATE-RGD	68Ga-NOTA-3PTATE-RGD; 68Ga-NOTA-3P-TATE-RGD	Phase 1 Clinical	Peking Union Medical College Hospital	Small Cell Lung Carcinoma; Neuroendocrine Tumors; Lung Neoplasms	Details
[99mTc]Tc-TECANT1		Phase 1 Clinical	Ljubljana University Medical Centre, Medical University Of Innsbruck, Narodowe Centrum Badan Jadrowych, Jagiellonian University Sylff Fellows Association	Neuroendocrine Tumors	Details
161Tb-DOTA-LM3	161Tb-DOTA-LM3	Phase 1 Clinical	University Hospital Basel	Pancreatic neuroendocrine tumors (pNET); Neuroendocrine Tumors	Details
44Sc-edotreotide	44Sc-edotreotide; 44Sc-DOTA-[3-Tyr]-octreotide; Sc44-DOTATOC	Clinical	Zentralklinik Bad Berka	Diagnostic agents	Details

Informations sur les médicaments commercialisés

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Plus ancien nom de marque	Pays d'approbation le plus ancien	Indication la plus ancienne	Société d'approbation la plus ancienne	Date d'approbation la plus ancienne	Indication	Essai clinique
Pasireotide Pamoate		Approved	Novartis Pharma Ag	Signifor lar	United States	Acromegaly	Recordati Rare Diseases Inc	2014-12-15	Gigantism; Acromegaly; Cushing Syndrome; Carcinoid Tumor; Pituitary ACTH Hypersecretion; Neuroendocrine Tumors; Meningioma	Details
Lutetium (177Lu) oxodotreotide	Lu-DOTATATE; Lutetium (177Lu) DOTA-TATE; 177Lu-DOTATATE; [Lu-177]-DOTATATE; AAA-601; F-1515; XTR-008; [177Lu]Lu-DOTA-TATE	Approved		Lutathera	EU	Neuroendocrine Tumors	Advanced Accelerator Applications Sa	2017-09-26	Breast Neoplasms; Carcinoid Heart Disease; Meningioma; Paraganglioma; Metastatic breast cancer; Lung Neoplasms; Carcinoma, Neuroendocrine; Pituitary Neoplasms; Medullary thyroid cancer (MTC); Neuroblastoma; Prostatic Neoplasms; Liver Neoplasms; Neuroendocrine Tumors; Malignant Carcinoid Syndrome; Pancreatic neuroendocrine tumors (pNET); Pancreatic Neoplasms; Adenoma, Islet Cell; Bronchial Neoplasms; Carcinoid Tumor; Pheochromocytoma; Leiomyosarcoma	Details
Vapreotide Acetate	RC-160; BMY-41606	Approved	Debiopharm Group	Sanvar, Docrised, Sanvar IR, Sanvar SR					Acromegaly; Hypertension, Portal; Pancreatic Neoplasms; Hemorrhage; Neuroendocrine Tumors; Diarrhea; Intraoperative Complications; Postoperative Complications; Esophageal and Gastric Varices; Crohn Disease	Details
Pasireotide Diaspartate	SOM-230; SOM-230C; SOM-320	Approved	Novartis Pharma Ag	Signifor, 丝尼芬	EU	Cushing Syndrome	Recordati Rare Diseases Inc	2012-04-24	Pituitary Neoplasms; Uveal melanoma; Prostatic Neoplasms, Castration-Resistant; Cysts; Pituitary ACTH Hypersecretion; Medullary thyroid cancer (MTC); Prostatic Neoplasms; Hyperinsulinism; Nelson Syndrome; Multiple Myeloma; Thyroid Neoplasms; Thymoma; Meningioma; Prolactinoma; Gastrointestinal Neoplasms; Carcinoma, Hepatocellular; Cluster Headache; Acromegaly; Neuroendocrine Tumors; Liver Cirrhosis; Kidney Diseases; Small Cell Lung Carcinoma; Pancreatic Neoplasms; Neoplasms; Adenoma, Islet Cell; Hypoglycemia; Dumping Syndrome; Insulinoma; Carcinoid Tumor; Cushing Syndrome; Alcohol-Induced Disorders; Congenital Hyperinsulinism; ACTH Syndrome, Ectopic	Details
Ga-68 Edotreotide	SMT-487; [68Ga]DOTATOC; 90Y-DOTATOC	Approved		SomaKit TOC, Gallium Dotatoc Ga 68, TOCscan	EU	Diagnostic agents; Neuroendocrine Tumors; Pancreatic neuroendocrine tumors (pNET)	Advanced Accelerator Applications Sa	2016-12-08	Medulloblastoma; Multiple Endocrine Neoplasia Type 1; Carcinoid Tumor; Pancreatic neuroendocrine tumors (pNET); Neuroendocrine Tumors; Neuroblastoma; Pituitary Neoplasms; Diagnostic agents; von Hippel-Lindau Disease; Somatostatinoma; Meningioma; Paraganglioma	Details
Gallium (68Ga) oxodotreotide	68Ga-DOTA-TATE; 68-Ga-DOTA-TATE	Approved		Netspot	United States	Neuroendocrine Tumors	Aaa Usa Inc	2016-06-01	Pheochromocytoma; Carcinoid Tumor; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Neuroendocrine Tumors; Prostatic Neoplasms; Thyroid Neoplasms; Carcinoma, Neuroendocrine; von Hippel-Lindau Disease; Paraganglioma; Carcinoma, Hepatocellular	Details