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Page d'accueilToutes les moléculesPlasma Kallikrein/KLKB1
Plasma Kallikrein/KLKB1
Plasma Kallikrein/KLKB1 Informations sur la molécule
| Nom anglais | Plasma kallikrein | Nombre de médicaments commercialisés | 4 |
| Nombre de médicaments cliniques | 13 | Alias de la cible | EC:3.4.21.34，EC 3.4.21，Fletcher factor，Plasma prekallikrein，KLKB1，Kallikrein B1，Kallikrein B， Plasma (Fletcher Factor) 1，Kininogenin，KLK3，PKK，Plasma Kallikrein，EC 3.4.21.34，PKKD，PPK，PKal，pKAL |
| Phase de R&D la plus avancée | Approved | ||
| Nom anglais | Plasma kallikrein |
| Alias de la cible | EC:3.4.21.34，EC 3.4.21，Fletcher factor，Plasma prekallikrein，KLKB1，Kallikrein B1，Kallikrein B， Plasma (Fletcher Factor) 1，Kininogenin，KLK3，PKK，Plasma Kallikrein，EC 3.4.21.34，PKKD，PPK，PKal，pKAL |
| Nombre de médicaments commercialisés | 4 |
| Nombre de médicaments cliniques | 13 |
| Phase de R&D la plus avancée | Approved |
Plasma Kallikrein/KLKB1 Liste de produits
- Attribut
Protein (3)
- Bibliothèque de produits
En ligne (3)
- Espèces
Mouse (1)Human (1)Cynomolgus (1)
- Étiquette
His Tag (3)
- Marqueur
Unconjugated (3)
| Numéro de produit | Espèces | Système d'expression | Description du produit | Structure protéique | Pureté | Caractéristiques | Pré-commande/Commande |
|---|---|---|---|---|---|---|---|
KL1-H52H9 |  Human | HEK293 | Human Plasma Kallikrein / KLKB1 Protein, His Tag (Pro-form, MALS verified) |  |  |  Ajouter au panier | |
KL1-M52H9 |  Mouse | HEK293 | Mouse Plasma Kallikrein / KLKB1 Protein, His Tag (active enzyme) |  | | Ajouter au panier | |
KL1-C52H3 |  Cynomolgus | HEK293 | Cynomolgus Plasma Kallikrein / KLKB1 Protein, His Tag (active enzyme, MALS verified) |  | | Ajouter au panier |
Quantité totale3
- 1
Plasma Kallikrein/KLKB1Contexte de la molécule
Human Plasma Kallikrein, a serine protease, is synthesized in the liver and circulates in the plasma by binding to high molecular weight (HMW) kininogen or as a free zymogen. The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
Plasma Kallikrein/KLKB1Alias de la molécule
Fletcher factor,kallikrein B, plasma (Fletcher factor) 1,kininogenin,KLK3 plasma kallikrein,KLKB1,plasma kallikrein heavy chain,plasma kallikrein light chain,Plasma Kallikrein,Plasma Prekallikrein,PPK,KLKB1
Informations sur les médicaments cliniques
| Nom anglais | Code de recherche | Phase de R&D | Entreprise | Indication | Essai clinique |
|---|---|---|---|---|---|
| Navenibart | QLS-215; STAR-0215 | Phase 3 Clinical | Quellis Biosciences Inc | Angioedemas, Hereditary | Details |
| ADX-324 | ADX-324; ADX324 | Phase 3 Clinical | ADARx Pharmaceuticals Inc | Angioedemas, Hereditary | Details |
| Lonvoguran Ziclumeran | NTLA-2002 | Phase 3 Clinical | Intellia Therapeutics Inc | Angioedemas, Hereditary | Details |
| THR-149 | TG-758; THR-149 | Phase 2 Clinical | Bicycle Therapeutics, Thrombogenics Inc | Diabetes Mellitus; Diabetic macular oedema; Diabetic Retinopathy | Details |
| BW-20805 | BW-20805; BW20805 | Phase 2 Clinical | Hangzhou Bolin Pharmaceutical Technology Co Ltd | Angioedemas, Hereditary | Details |
| MDPK-67b | DM-107; MDPK-67; MDPK-67b; MDKP 67b; RIK-7 | Phase 1 Clinical | Med Discovery | Prostatic Neoplasms | Details |
| MSB-03 | MSB-03 | Phase 1 Clinical | MatriSys Bioscience Inc | Rosacea | Details |
| Avoralstat | BCX-V; BCX-4161 | Phase 1 Clinical | Biocryst Pharmaceuticals Inc | Angioedemas, Hereditary; Diabetic macular oedema | Details |
| ADX-324(Tenacia) | ADX324; ADX-324 | Phase 1 Clinical | Yuanyi Biotechnology (Shanghai) Co., Ltd. | Angioedemas, Hereditary | Details |
| ZKLJ-02 | Phase 1 Clinical | Kunming Longjin Pharmaceutical Co Ltd | Cardiovascular Diseases; Ischemic Stroke; Nervous System Diseases; Stroke | Details | |
| ATN-249 | ATN-249 | Phase 1 Clinical | Attune Pharmaceuticals | Angioedemas, Hereditary | Details |
| BI-Z | Clinical | Boehringer Ingelheim Pharma Gmbh & Co Kg | Wet Macular Degeneration | Details | |
| mRNA encoded Cas9 targeting human KLKB 1 gene therapy (Pharma Gateway) | Clinical | Pharma Gateway AB | Angioedemas, Hereditary | Details |
Informations sur les médicaments commercialisés
| Nom anglais | Code de recherche | Phase de R&D | Entreprise | Plus ancien nom de marque | Pays d'approbation le plus ancien | Indication la plus ancienne | Société d'approbation la plus ancienne | Date d'approbation la plus ancienne | Indication | Essai clinique |
|---|---|---|---|---|---|---|---|---|---|---|
| Lanadelumab | 2372V1TKXK (UNII code); X124-G01; SHP-643; DX-2930; TAK-743 | Approved | Dyax Pharma | Takhzyro, 达泽优 | United States | Angioedemas, Hereditary | Dyax Corp | 2018-08-23 | Angioedema; Angioedemas, Hereditary; Coronavirus Disease 2019 (COVID-19); Hereditary Autoinflammatory Diseases; Lung Injury | Details |
| Berotralstat | BCX-7353 | Approved | Biocryst Pharmaceuticals Inc | ORLADEYO | United States | Angioedemas, Hereditary | Biocryst Pharmaceuticals Inc | 2020-12-03 | Angioedemas, Hereditary | Details |
| Ecallantide | DX-88; EPI-KAL2; FOV-2302; CB-500929 | Approved | Dyax Pharma | Kalbitor | United States | Angioedema | Dyax Corp | 2009-12-01 | Angioedema; Angioedemas, Hereditary; Blood Loss, Surgical; Hemorrhage; Hereditary Angioedema Types I and II; Macular Edema; Retinal Vein Occlusion | Details |
| Sebetralstat | KVD-900 | Approved | Vantia Therapeutics Ltd. | Ekterly | United States | Angioedemas, Hereditary | Kalvista Pharmaceuticals Ltd, Kalvista Pharmaceuticals Inc | 2025-07-03 | Angioedemas, Hereditary | Details |
- Informations sur la molécule
- Liste de produits
- Informations sur les médicaments commercialisés
- Informations sur les médicaments cliniques
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