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Cynomolgus / Rhesus macaque CD19 (20-279) Superstable Mutant Protein, His Tag (MALS verified)

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CD9-C52H6-100ug
$485.00
CD9-C52H6-1mg (500ug X 2)
$3265.00
ETA of in-stock products:2 business days
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Détails du produit

  • Synonyms

    CD19, B4, CVID3, MGC12802

  • Source

    Cynomolgus / Rhesus macaque CD19 (20-279) Superstable Mutant Protein, His Tag (CD9-C52H6) is expressed from human 293 cells (HEK293). It contains AA Pro 20 - Pro 279 (Accession # F7F486-1). In the region Pro 20 - Pro 279, the amino acid sequences of Cynomolgus and Rhesus macaque CD19 are identical.

    Predicted N-terminus: Pro 20

    Request for sequence

  • Molecular Characterization

    CD19 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 30.4 kDa. The protein migrates as 40-60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

    Within the expressed region, several mutations were introduced to optimize the protein expression and stability.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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  • SDS-PAGE

    CD19 SDS-PAGE

    Cynomolgus / Rhesus macaque CD19 (20-279) Superstable Mutant Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    CD19 SEC-MALS

    The purity of Cynomolgus / Rhesus macaque CD19 (20-279) Superstable Mutant Protein, His Tag (Cat. No. CD9-C52H6) is more than 85% and the molecular weight of this protein is around 40-55 kDa verified by SEC-MALS.

    Report

  • Bioactivity-ELISA

    CD19 ELISA

    Immobilized Cynomolgus / Rhesus macaque CD19 (20-279) Superstable Mutant Protein, His Tag (Cat. No. CD9-C52H6) at 5 μg/mL (100 μL/well) can bind Human Anti-CD19, Human IgG1 with a linear range of 1-63 ng/mL (QC tested).

    Protocol

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Introduction de fond

B-lymphocyte antigen CD19 is also known as CD19 (Cluster of Differentiation 19), is a single-pass type I membrane protein which contains two Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. It primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Src-family kinases and recruitment of PI-3 kinase. As on T cells, several surface molecules form the antigen receptor and form a complex on B lymphocytes. The (almost) B cell-specific CD19 phosphoglycoprotein is one of these molecules. The others are CD21 and CD81. These surface immunoglobulin (sIg)-associated molecules facilitate signal transduction. On living B cells, anti-immunoglobulin antibody mimicking exogenous antigen causes CD19 to bind to sIg and internalize with it. The reverse process has not been demonstrated, suggesting that formation of this receptor complex is antigen-induced. This molecular association has been confirmed by chemical studies. Mutations in CD19 are associated with severe immunodeficiency syndromes characterized by diminished antibody production. CD19 has been shown to interact with: CD81, CD82, Complement receptor 2, and VAV2.

Progrès de frontière

 
Progrès du développement médicamenteux
  • Nom anglais：

    B-lymphocyte antigen CD19

  • Catégorie：

  • Nombre de médicaments répertoriés：

    14 Détails

  • Nombre de médicaments cliniques：

    435 Détails

  • Étape de développement la plus élevée：

    Approved

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