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Chikungunya virus (CHIKV) E3 & E2 & E1 Protein, His Tag (MALS verified)

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E3P-V52H3-50ug
$472.00
In Stock - Delivery in 1-2 business days
E3P-V52H3-500ug
$2,940.00
In Stock - Delivery in 2 weeks
E3P-V52H3
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Synonyms

E3 & E2 & E1

Source

Chikungunya virus (CHIKV) E3 & E2 & E1 Protein, His Tag (E3P-V52H3) is expressed from human 293 cells (HEK293). It contains AA Pro 266 - Arg 325 & Ser 326 - Gln 666 & Tyr 810 - Pro 1200 (Accession # Q1H8W5).

Predicted N-terminus: Pro 266

Molecular Characterization

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 90.6 kDa. The protein migrates as 85-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

The protein is designed as a dimer.

Purity

>90% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System

Introduction de fond

Chikungunya virus (CHIKV) p62 is a structural polyprotein precursor that undergoes furin-mediated cleavage to generate the E3 and E2 glycoproteins. Co-translational association with the fusion protein E1 in the endoplasmic reticulum produces p62–E1 heterodimers that ensure proper folding and spike assembly. Following E3 removal, the mature E2–E1 complex organizes into trimeric spikes on the virion surface, mediating receptor binding and pH-triggered membrane fusion during cell entry. This coordinated processing is essential for CHIKV infectivity and immunogenicity, driving efficient virus assembly.