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PE-Labeled Human HLA-A*02:01&B2M&hTERT (ILAKFLHWL) Tetramer Protein

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Numéro de produit/spécification
Prix
Qté
HLT-HP2H5-25ug
$410.00
HLT-HP2H5-200ug (100ug X 2)
$2350.00
ETA of in-stock products:2 business days
Total des articles Montant du produit$ 0

Détails du produit

  • Synonyms

    HLA-A*0201 & B2M & hTERT (ILAKFLHWL)

  • Source

    PE-Labeled Human HLA-A*02:01&B2M&hTERT (ILAKFLHWL) Tetramer Protein (HLT-HP2H5) is expressed from human 293 cells (HEK293). It contains AA Gly 25 - Ile 308 (HLA-A*02:01) & Ile 21 - Met 119 (B2M) & ILAKFLHWL peptide (Accession # AAA59606.1 (HLA-A*02:01) & P61769 (B2M) & ILAKFLHWL).

    Predicted N-terminus: Gly 25 & Ile 21

  • Molecular Characterization

    PE-Labeled Human HLA-A*02:01&B2M&hTERT (ILAKFLHWL) Tetramer Protein is assembled by biotinylated monomer and PE-labeled streptavidin.

    Biotinylated Human HLA-A*02:01&B2M&hTERT (ILAKFLHWL) Complex Protein is produced by co-expression of HLA and B2M loaded with hTERT peptide. Biotinylated Human HLA-A*02:01&B2M&hTERT (ILAKFLHWL) Complex Protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™).

  • Conjugate

    PE

    Excitation Wavelength: 488 nm / 561 nm

    Emission Wavelength: 575 nm

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, 1% BSA, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Introduction de fond

hTERT (human Telomerase Reverse Transcriptase), the catalytic subunit of telomerase, maintains telomere length to drive tumor cells’ unlimited proliferation. It is highly expressed in ~85-90% of cancers but silenced in most normal somatic cells. The peptide ILAKFLHWL (from hTERT residues 540-548) acts as a tumor-specific antigen. It binds to MHC class I molecule HLA-A0201 to form a surface complex on tumors, activating cytotoxic T lymphocytes (CTLs). The Human HLA-A*0201 hTERT (ILAKFLHWL) complex protein is a complex of HLA-A*0201 of the MHC Class I, B2M, and ILAKFLHWL peptide of the hTERT.

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