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Cynomolgus Integrin alpha 3 beta 1 (ITGA3&ITGB1) Heterodimer Protein, His Tag&Tag Free

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IT1-C52W6-100ug
$470.00
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IT1-C52W6-1mg
$3,290.00
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IT1-C52W6
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Product Details
Performance Data
Reviews & Citations
Resources
  • Product Details
  • Performance Data
  • Reviews & Citations
  • Important Statement
  • Resources
Synonyms

Integrin alpha 3 beta 1, ITGA3&ITGB1

Source

Cynomolgus ITGA3&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-C52W6) is expressed from human 293 cells (HEK293). It contains AA Phe 30 - Glu 988 (ITGA3) & Gln 161 - Asp 868 (ITGB1) (Accession # A0A2K5VFM7 (ITGA3) & A0A7N9D0D7 (ITGB1)).

Predicted N-terminus: Phe 30 (ITGA3) & Gln 161 (ITGB1)

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

Cynomolgus ITGA3&ITGB1 Heterodimer Protein, His Tag&Tag Free produced by co-expression of ITGA3 and ITGB1, has a calculated MW of 127.5 kDa (ITGA3) & 83.6 kDa (ITGB1). Subunit ITGA3 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus. The protein has a calculated MW of 113.1 kDa (ITGA3) & 83.6 kDa (ITGB1). The protein migrates as 110-150 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 1.0 EU per μg by the LAL method / rFC method.

Purity

>90% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System

Background

Integrin alpha 3 beta 1 is a crucial receptor involved in various biological processes, including cell adhesion, migration, and invasion. It is composed of an alpha subunit (ITGA3) and a beta subunit (ITGB1), which together form the integrin alpha 3 beta 1 complex. This complex plays a significant role in the formation of invadopodia, which are cell membrane protrusions that facilitate cell invasion. The integrin alpha 3 beta 1 complex interacts with various extracellular matrix proteins, such as fibronectin, laminin, and collagen, and is involved in processes like matrix degradation and cell invasion. It is also implicated in the maturation of integrin beta 1, which is essential for cell survival and growth.