Détails du produit
Synonyms
betaKlotho, beta-klotho, BKL, KLB, klotho beta like, klotho beta-like protein
Source
Cynomolgus / Rhesus macaque Klotho beta Protein, His Tag (KLB-R52H8) is expressed from human 293 cells (HEK293). It contains AA Phe 53 - Leu 997 (Accession # G7MSR8-1). In the region Phe 53 - Leu 997, the amino acid sequences of Cynomolgus and Rhesus macaque Klotho beta are identical.
Predicted N-terminus: Phe 53
Request for sequenceMolecular Characterization

Other Tags and Version Biotin & Other Labeled Version
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 110.3 kDa. The protein migrates as 115-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 1.0 EU per μg by the LAL method / rFC method.
Purity
>95% as determined by SDS-PAGE.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Shipping and Storage
This product is shipped at ambient temperature.
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System
Les clients ont également consulté
Affichage des données
SDS-PAGE

Cynomolgus / Rhesus macaque Klotho beta Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.
Bioactivity-BLI

Loaded Human FGF R4, Fc Tag (Cat. No. FG4-H5253) on Protein A Biosensor, can bind Cynomolgus / Rhesus macaque Klotho beta Protein, His Tag (Cat. No. KLB-R52H8) with an affinity constant of 0.9 μM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).
Protocol
Loaded Human FGF19, Fc Tag (Cat. No. FG9-H5253) on Protein A Biosensor, can bind Cynomolgus / Rhesus macaque Klotho beta Protein, His Tag (Cat. No. KLB-R52H8) with an affinity constant of 78.5 nM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).
Protocol
Avis des utilisateurs Publier un commentaire

Introduction de fond
Progrès de frontière
- Nom anglais:
Klotho beta
- Catégorie:
- Nombre de médicaments répertoriés:
0 Détails
- Nombre de médicaments cliniques:
3 Détails
- Étape de développement la plus élevée:
Phase 2 Clinical



















