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Biotinylated Human LILRB1 / CD85j / ILT2 Protein, His,Avitag™ (MALS verified)

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Numéro de produit/spécification
Prix
Qté
CDJ-H82E8-25ug
$380.00
CDJ-H82E8-200ug
$1645.00
ETA of in-stock products:2 business days
Total des articles Montant du produit$ 0

Détails du produit

  • Synonyms

    CD85J, LILRB1, CD85, ILT2, LIR1, MIR7

  • Source

    Biotinylated Human LILRB1 Protein, His,Avitag (CDJ-H82E8) is expressed from human 293 cells (HEK293). It contains AA Ala 23 - Thr 431 (Accession # Q8NHL6-1).

    Predicted N-terminus: Ala 23

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  • Molecular Characterization

    LILRB1 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™).

    The protein has a calculated MW of 48.2 kDa. The protein migrates as 52-64 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Labeling

    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

  • Protein Ratio

    Passed as determined by the HABA assay / binding ELISA.

  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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  • SDS-PAGE

    LILRB1 SDS-PAGE

    Biotinylated Human LILRB1 Protein, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    LILRB1 SEC-MALS

    The purity of Biotinylated Human LILRB1 Protein, His,Avitag (Cat. No. CDJ-H82E8) is more than 95% and the molecular weight of this protein is around 50-65 kDa verified by SEC-MALS.

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Introduction de fond

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Progrès de frontière

 
Progrès du développement médicamenteux
  • Nom anglais:

    Leukocyte immunoglobulin-like receptor B1

  • Catégorie:

  • Nombre de médicaments répertoriés:

    0 Détails

  • Nombre de médicaments cliniques:

    7 Détails

  • Étape de développement la plus élevée:

    Phase 2 Clinical

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