user
cart
menu
orderQuote Inquiry / OrdercartCart
letter
Sign InRegister
langEnglisharrow
1/9
+6 View all
COADS MSDS

HRSV (A) Post-fusion glycoprotein F0, His Tag (MALS verified)

1/9
+6 View all
COADS MSDS
Numéro de produit/spécification
Prix
Availability
Qté
RSF-V52H6-50ug
$465.00
In Stock - Delivery in 1-2 business days
RSF-V52H6-500ug
$3,170.00
In Stock - Delivery in 1-2 business days
RSF-V52H6
Montant du produit :
$ 0
0
Ajouter au panier
Suggestion de nouveau produit Request Quote
Contact Us
Contact Us
Montant du produit:
$ 0
0
Ajouter au panier
Request Quote
Détails du produit
Affichage des données
Reviews & Citations
Resources
Ajouter au panier
  • Détails du produit
  • Affichage des données
  • Reviews & Citations
  • Important Statement
  • Resources
Synonyms

Postfusion glycoprotein F0/post-F protein (RSV)

Source

HRSV (A) Post-fusion glycoprotein F0, His Tag (RSF-V52H6) is expressed from human 293 cells (HEK293).

Molecular Characterization

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 55.2 kDa. The protein migrates as 47-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Within the expressed region, several mutations were introduced to optimize the protein expression and stability.

The protein is designed as a trimer.

Endotoxin

Less than 1.0 EU per μg by the LAL method / rFC method.

Purity

>95% as determined by SDS-PAGE.

>95% as determined by SEC-MALS.

Formulation

Lyophilized from 0.22 μm filtered solution in 0.1 M Sodium citrate, 150 mM NaCl, pH5.5 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

After reconstitution, this product is stable after storage at -70°C for 3 months.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • For long term storage, the product is stable for up to 3 years at -70°C from date of receipt;
  • For short term storage, the product is stable for up to 3 months at 2-8°C from date of receipt.
ACRO Quality Management System

Introduction de fond

Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. The RSV fusion glycoprotein (RSV F) is the principal target of RSV neutralizing antibodies in human sera. The RSV F is a type I viral fusion protein synthesized as inactive, single-chain polypeptides that assemble into trimers. RSV F fuses the viral and host cell membranes by irreversible protein refolding from the labile prefusion conformation to the stable post-fusion conformation. Both states exhibit epitopes targeted by neutralizing antibodies, and post-fusion RSV F is being developed as a vaccine candidate.