user
menu
letter
Sign InRegister
langEnglisharrow

ActiveMax® Beads

ActiveMax® is our brand of biocompatible magnetic beads pre-conjugated with our own highly active recombinant proteins designed for cell activation, culture, and other application scenarios. Our ActiveMax® products are manufactured with strict quality requirements for cell manufacturing use including animal origin-free, sterile, mycoplasma free, and ultralow endotoxins. This ensures that our products meet all of your needs for immune cell therapy related research to preclinical process development, before seamlessly transitioning to GMP-grade.

In addition, we also provide sterile cell-grade streptavidin magnetic beads, which can help you quickly achieve personalized preparation of various cell-grade protein/antibody-coupled magnetic beads.

Click to Customize ActiveMax® Conjugated μBeads

ActiveMax® Beads

  • Target-specific Magnetic Beads
  • Antibody-coupled Magnetic Beads
  • Streptavidin-coupled Magnetic Beads
  • Custom Services

Target-specific Magnetic Beads

Feature: Target-specific Activation Beads

Target-specific Magnetic Beads

MBS-C002

Target-specific Magnetic Beads

MBS-C003

Target-specific Magnetic Beads

MBS-C004


Pre-coupled with our high-quality proteins


Sterile, Ultralow endotoxin (< 2 EU/mg)


Support cell activation, expansion, enrichment, and in vitro anaylsis


Readily available with stable, continuous supply


High batch-to-batch consistency

CD19DLL4BCMAMLSNHER2CD7CD22FMC63 scFv4-1BB/4-1BBLCD80/CD86Streptavidin…

Click here to customize more targets.

Inquiry / Quotation

Popular Applications of Target-specific Activation Beads
Popular Applications of Target-specific Activation Beads

CAR Cell Activation and Expansion

The use of antigenic polymers based on magnetic bead coupled can effectively activate CAR-T cells with specificity.

Popular Applications of Target-specific Activation Beads

CAR Cell In Vitro Analysis

After co-incubation with CAR-T cells using target-specific activation beads, in vitro analyses such as T cell activation, proliferation, and cytokine release were performed to locate product characterization and release testing.

Popular Applications of Target-specific Activation Beads

CAR Cell Enrichment

Target-specific magnetic beads can be used to enrich low abundance CAR cells or rare CAR-T cells

Typical Data

Streptavidin-coupled Magnetic Beads

BCMA CAR-T cells were stimulated with ActiveMax® Human BCMA μBeads (MBS-C004) for 24 h , and cell-free supernatants were harvested for evaluating IFN-γ、TNF-α、IL-4、IL-6 secretion by flow cytomtry. The results showed that BCMA CAR-T cells released significantly larger amounts of IFN-γ、TNF-α、IL-4、IL-6 into the supernatants in response to BCMA μBeads.

Antibody-coupled Magnetic Beads

Hot Product: GMP-grade Anti-CD3/CD28 Antibody-coupled Magnetic Beads
Antibody-coupled Magnetic Beads


Single-step cell sorting & activation


Compatible with general cell medias for worry-free cell culturing


Improved retention of naive & memory T cell phenotypes


High product stability and safety


DMF-filed product for FDA biologics applications

Inquiry / Quotation

Learn More

Streptavidin-coupled Magnetic Beads

Feature: Sterile Streptavidin-coupled Magnetic Beads
Streptavidin-coupled Magnetic Beads

Inquiry / Quotation

Learn More

Typical Data

Streptavidin-coupled Magnetic Beads

ActiveMax Streptavidin coupled μbeads, premium grade coupled with protein. 40ug of the biotinylated human BCMA protein (Cat. No. BCA-H82E4) was added to 1mg of ActiveMax Streptavidin coupled μbeads, premium grade (for cells) (Cat. No. MBS-C009), mix well and incubate for 60 mins at room temperature. And then the coupled μbeads were fluorescently stained using PE labeled anti-human BCMA antibody and analyzed by flow cytometry.

Streptavidin-coupled Magnetic Beads

ActiveMax Streptavidin coupled μbeads, premium grade coupled with human BCMA protein. The biotinylated human BCMA protein (Cat. No. BCA-H82E4) in serial dose was added to 1mg of ActiveMax Streptavidin coupled μbeads, premium grade (for cells) (Cat. No. MBS-C009), mix well and incubate for 60 mins at room temperature. And then the unbound protein in supernatant measured by Micro BCA Protein Assay Kit was subtracted to calculate the BCMA protein coupled amount on the μbeads (loaded capacity).

Streptavidin-coupled Magnetic Beads

ActiveMax Streptavidin coupled μbeads, premium grade coupled with antibody. 50ug of the biotinylated anit-FMC63 Antibody (Cat. No. FM3-BY54) was added to 1mg of ActiveMax Streptavidin coupled μbeads, premium grade (for cells) (Cat. No. MBS-C009), mix well and incubate for 60 mins at room temperature. And then the coupled μbeads were fluorescently stained using PE labeled anti-mouse Fc antibody and analyzed by flow cytometry.

Streptavidin-coupled Magnetic Beads

ActiveMax Streptavidin coupled μbeads, premium grade coupled with antibody. The anit-FMC63 Antibody (Cat. No. FM3-BY54) in serial dose was added to 1mg of ActiveMax Streptavidin coupled μbeads, premium grade (for cells) (Cat. No. MBS-C009), mix well and incubate for 60 mins at room temperature. And then the unbound protein in supernatant measured by Micro BCA Protein Assay Kit was subtracted to calculate the antibody coupled amount on the μbeads (loaded capacity).

Custom Services

Custom Services
Custom Services

We are dedicated to delivering highly specialized solutions for cell therapy and a range of other applications. Utilizing the advanced capabilities of the ActiveMax platform, we provide bespoke coupled magnetic bead products tailored to your precise research requirements, thereby expediting your drug development journey.

Customize your ActiveMax magnetic beads

Our Advantages

Different conjugation methods, different bead sizes, Tailor the beads to your specific research needs.

Personalization

Thousands of target proteins are ready-made and provided for free in coupled Magnetic Beads.

Comprehensive Proteins

Maintain high standards with sterile, animal origin-free, and ultra-low endotoxin products.

Stringent Quality Control

A robust GMP quality management system ensures a seamless transition from early development to clinical production.

Seamless Transition to GMP-grade

FAQ

Q

How do ActiveMax® CD3/CD28 Beads drive polyclonal T-cell activation and expansion compared to soluble antibody cocktails?

Soluble antibodies often require Fc receptor-mediated cross-linking on feeder cells to induce robust signal transduction. ActiveMax® CD3/CD28 Beads provide co-immobilized anti-CD3 (Signal 1) and anti-CD28 (Signal 2) recombinant monoclonal antibodies on biocompatible magnetic beads. This rigid, multivalent presentation mimics physiological antigen-presenting cell (APC) contact, triggering rapid T-cell receptor (TCR) clustering, IL-2 secretion, and sustained polyclonal expansion of T cells without requiring feeder cells or causing premature T-cell exhaustion.
Q

What stringent quality standards govern ActiveMax® Beads to meet cell therapy CMC release and regulatory compliance?

Reagents used as ancillary materials in cell and gene therapy (CGT) manufacturing must comply with global regulatory guidelines. ActiveMax® products are manufactured under a strict quality management system. They are certified animal origin-free (AOF), sterile, mycoplasma-free, and contain ultra-low endotoxin levels. These controls prevent pyrogenic responses, non-specific immune pre-activation, and adventitious viral contamination during primary immune cell processing.
Q

What pre-conjugated antigen magnetic beads are available in the ActiveMax® portfolio, and how do they support cell-based research?

The ActiveMax® portfolio offers a broad selection of pre-conjugated magnetic beads coupled with biologically active recombinant target proteins, covering popular targets such as CD19, BCMA, and DLL4. Ready to use without additional conjugation, these beads simplify experimental workflows and improve reproducibility. Leveraging highly bioactive recombinant antigens and exceptional antigen-binding specificity, they are well suited for applications including magnetic cell isolation, antigen-specific CAR-T cell enrichment, cell binding validation, immune cell activation, and cell lineage differentiation studies. Designed to support workflows from basic research through process development and large-scale manufacturing, ActiveMax® magnetic beads provide a reliable solution for advancing cell therapy research and development.
Q

How does the magnetic separation process ensure complete bead removal before final cell therapy formulation?

In adoptive cell therapy manufacturing, residual beads in the final injectable product pose safety and regulatory risks. ActiveMax® Beads feature uniform superparamagnetic cores that respond rapidly to external magnetic fields during magnetic separation columns or tube racks. Following cell expansion or isolation, cells are passed through a magnetic separator; the magnetic beads are captured while the unlabelled, activated cells flow through smoothly. Quantitative residual bead assays (such as flow cytometry or microscopic particle counting) verify that bead clearing meets clinical release thresholds.
Q

What is the core design philosophy of ActiveMax® Beads, and how do they facilitate the transition from preclinical R&D to GMP production?

ActiveMax® is ACROBiosystems’ dedicated brand of biocompatible magnetic beads pre-conjugated with high-activity recombinant target proteins. To prevent process re-validation delays when advancing candidate cell therapies into clinical trials, ActiveMax® Beads utilize identical chemical matrices, conjugation chemistries, and bioactivity testing protocols across both research-grade and GMP-grade tiers. This consistency allows researchers to establish cell activation, sorting, and expansion protocols early in preclinical development and seamlessly transition to GMP manufacturing.
Q

What supply and customization services are available for ActiveMax® target-specific magnetic beads?

ActiveMax® offers a stable inventory of PG-grade magnetic beads targeting popular antigens such as CD19, BCMA, and CD22. We also provide custom development services for rare targets, customized antigen coupling densities, and GMP-grade magnetic beads to meet specific research and manufacturing requirements. Comprehensive technical documentation is available, including Certificates of Analysis (COAs), quality control reports, process validation data, and cell-based experimental protocols, ensuring efficient implementation from research through process development.
Q

Why is ultra-low endotoxin control critical when using magnetic beads in primary T-cell and NK-cell cultures?

Primary human lymphocytes—including CD8+ T cells, CD4+ T cells, and NK cells—express innate pattern recognition receptors (such as Toll-like Receptor 4, TLR4) that react to lipopolysaccharide (LPS) endotoxin contamination. Even picogram levels of endotoxin can induce aberrant cytokine secretion (TNF-α, IL-6), alter memory cell differentiation, or trigger cell apoptosis. By maintaining ultra-low endotoxin specifications, ActiveMax® Beads preserve clean, unconfounded cellular responses and consistent T-cell memory phenotypes during ex vivo cell culture.
Q

What advantages do ActiveMax® target-specific magnetic beads offer over tumor cell lines for in vitro CAR-T potency assays?

Traditional potency assays rely on tumor cell lines stably expressing target antigens, which often involve labor-intensive cell culture, variable antigen expression across batches, limited assay reproducibility, and challenges in standardization. ActiveMax® magnetic beads feature precisely controlled surface antigen density, eliminating the need for live tumor cell culture while enabling standardized, antigen-specific activation of CAR-T cells. This provides a more consistent, reproducible, and scalable platform for in vitro CAR-T potency assessment.
  • Background
  • ActiveMax® Beads
  • FAQ