B21R

Demande de produit

B21RContexte de la molécule

Monkeypox is a rare zoonosis caused by monkeypox virus, which has become the most serious orthpoxvirus and consists of complex double stranded DNA. The cases are mostly in central and western Africa. The pathogenesis of monkeypox is that the virus invades the body from respiratory mucosa, multiplies in lymphocytes, and incurs into blood producing transient venereal toxemia. after the virus multiplies in cells, the cells can invade the blood and propagate to the skin of the whole body, causing lesions. The important target protein B21R with key immune dominant epitopes is considered to be the focus of monkeypox virus research.

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
BLU-782	BLU-782; IPN-60130	Phase 2 Clinical	Blueprint Medicines Corp, Ipsen SA	Myositis Ossificans	Details
Zilurgisertib	INCB-000928; INCB-00928	Phase 2 Clinical	Incyte Corp	Anemia; Polycythemia Vera; Myelodysplastic Syndromes; Kidney Diseases; Ossification, Heterotopic; Multiple Myeloma; Myositis Ossificans; Primary Myelofibrosis; Thrombocythemia, Essential	Details
KER-047	KER-047	Phase 1 Clinical	National Center For Advancing Translational Sciences	Anemia, Iron-Deficiency; Myositis Ossificans	Details
Itacnosertib	TP-0184	Phase 1 Clinical	Tolero Pharmaceuticals Inc, Sumitomo Dainippon	Solid tumours; Anemia	Details
BCX-9250	BCX-9250	Phase 1 Clinical	Biocryst Pharmaceuticals Inc	Myositis Ossificans	Details

Informations sur les médicaments commercialisés

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Plus ancien nom de marque	Pays d'approbation le plus ancien	Indication la plus ancienne	Société d'approbation la plus ancienne	Date d'approbation la plus ancienne	Indication	Essai clinique
Momelotinib Dihydrochloride	CYT-387; GS-0387; GSK-3070785	Approved		Ojjaara, Omjjara	United States	Primary Myelofibrosis; Anemia	Glaxosmithkline Llc, Glaxosmithkline Plc	2023-09-15	Polycythemia; Polycythemia Vera; Anemia; Neoplasms; Myeloproliferative Disorders; Pancreatic Intraductal Neoplasms; Primary Myelofibrosis; Carcinoma, Pancreatic Ductal; Splenomegaly; Thrombocythemia, Essential; Carcinoma, Non-Small-Cell Lung	Details