CCL4 Informations sur la molécule
Molecule Name
C-C motif chemokine 4
Alias de la molécule
C-C motif chemokine 4,G-26 T-lymphocyte-secreted protein,HC21,Lymphocyte activation gene 1 protein,LAG-1,MIP-1-beta(1-69),Macrophage inflammatory protein 1-beta,MIP-1-beta,PAT 744,Protein H400,SIS-gamma,Small-inducible cytokine A4,T-cell activation protei
Drug Development Progress
Nombre de médicaments cliniques0
Nombre de médicaments commercialisés0
Phase de R&D la plus avancéePreclinical
Alias de la cible
LAG1，Secreted Protein G-26，Chemokine (C-C Motif) Ligand 4，C-C Motif Chemokine Ligand 4，AT744.1，ACT2，SCYA4，G-26，G-26 T-lymphocyte-secreted protein，HC21，Lymphocyte activation gene 1 protein，LAG-1，MIP-1-beta(1-69)，Macrophage inflammatory protein 1-beta，MIP-1-beta，PAT 744，Protein H400，T-cell activation protein 2，ACT-2，SCYA2，MIP1B1，MIP1B，SIS-gamma，Small-inducible cytokine A4
Contexte de la molécule
CCL4, also know as MIP-1-beta, is monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B