DR3 / TNFRSF25 Informations sur la molécule
Molecule Name
Tumor necrosis factor receptor superfamily member 25
Alias de la molécule
TNFRSF25,DR3,APO3,DDR3,TNFRSF12,WSL,WSL1
Drug Development Progress
Nombre de médicaments cliniques0
Nombre de médicaments commercialisés0
Phase de R&D la plus avancéePreclinical
Alias de la cible
Apo-3，Apoptosis-inducing receptor AIR，Apoptosis-mediating receptor DR3，Apoptosis-mediating receptor TRAMP，Death receptor 3，Lymphocyte-associated receptor of death，Protein WSL，DDR3，Death Receptor Beta，TNFRSF12，TRAMP，DR3，WSL-1，PH Domain-Containing Family G Member 5，PLEKHG5，WSL-LR，WSL1，APO3，WSL，TR3，TNF Receptor Superfamily Member 25，Death Domain Receptor 3 Soluble Form，GEF720，Guanine Nucleotide Exchange Factor 720，Apoptosis Inducing Receptor，Tumor Necrosis Factor Receptor Superfamily， Member 25，Pleckstrin Homology Domain-Containing Family G Member 5，Protein WSL-1，LARD，Tumor Necrosis Factor Receptor Superfamily， Member 12 (Translocating Chain-Association Membrane Protein)
Contexte de la molécule
Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) is also known as Apo-3, Death receptor 3 (DDR3 or DR3), Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor TRAMP, Lymphocyte-associated receptor of death, Apo-3, which is a member of the TNF-receptor superfamily. TNFRSF25 is a homodimer protein, which can Interact strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. TNFRSF25 is receptor for TNFSF12 / APO3L / TWEAK.