GDF-11

Demande de produit

GDF-11Contexte de la molécule

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging.

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
Recombinant humanized anti-IL-6R antibody (Hisun Pharma)	HS-628	Phase 3 Clinical	Zhejiang Hisun Pharmaceutical Co Ltd	Arthritis, Rheumatoid; Arthritis	Details
VDJ-001		Phase 3 Clinical	Beijing Vdjbio Co Ltd	Arthritis, Rheumatoid; Multicentric Castleman's Disease (MCD)	Details
Tocilizumab biosimilar (AryoGen Pharmed)		Phase 3 Clinical	Aryogen Biopharma	Arthritis, Rheumatoid	Details
CMAB806	CMAB-806	Phase 3 Clinical	Taizhou Maibo Taike Biotechnology Co Ltd	Arthritis, Rheumatoid; Arthritis	Details
Levilimab	BCD-089	Phase 3 Clinical	Biocad	Arthritis, Rheumatoid; Coronavirus Disease 2019 (COVID-19)	Details
Olamkicept	FE-999301; CR-5/18; TJ-301; FE-301	Phase 2 Clinical	Conaris Research Institute	Gastrointestinal Diseases; Colitis, Ulcerative	Details
Atexakin alfa	SON-080; r-IL-6	Phase 2 Clinical	Weizmann Institute Of Science	Peripheral Nervous System Diseases; Diabetic Neuropathies	Details
Tocilizumab Biosimilar (qyuns)	QX-003-S	Phase 1 Clinical	Qyuns Therapeutics Co Ltd	Arthritis, Rheumatoid	Details

Informations sur les médicaments commercialisés

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Plus ancien nom de marque	Pays d'approbation le plus ancien	Indication la plus ancienne	Société d'approbation la plus ancienne	Date d'approbation la plus ancienne	Indication	Essai clinique
Tocilizumab	rhPM-1; RO-48775533; RG-1569; MRA; HPM-1; MRA-SC; R-1569	Approved	Chugai Pharmaceutical Co Ltd	Actemra, RoActemra, 雅美罗, Actemra/RoActemra, Acterma	Japan	Arthritis, Juvenile; Arthritis, Rheumatoid; Giant Cell Arteritis; Takayasu Arteritis; Cytokine Release Syndrome; Multicentric Castleman's Disease (MCD)	null	2005-04-11	Lymphoma; Graves Ophthalmopathy; Ascites; Takayasu Arteritis; Pancreatitis, Chronic; Coronavirus Infections; Pulmonary Arterial Hypertension; Coronary Disease; Lupus Erythematosus, Systemic; Breast Neoplasms; systemic sclerosis-associated interstitial lung disease; Multicentric Castleman's Disease (MCD); Fever; Uveitis, Posterior; Stroke; Pulmonary Disease, Chronic Obstructive; Osteoarthritis; Uveitis; Rejection in heart transplantation; Inflammation; Pleural Effusion, Malignant; Panuveitis; Diabetes Mellitus; Behcet Syndrome; Amyotrophic Lateral Sclerosis; Anemia, Sickle Cell; Carcinoma, Hepatocellular; Non-ST Elevated Myocardial Infarction; Myocardial Infarction; Hematologic Neoplasms; Solid tumours; Cytokine Release Syndrome; Motor Neuron Disease; HIV Infections; Diabetes Mellitus, Type 1; Acute Chest Syndrome; Craniopharyngioma; Polymyositis; Giant Cell Arteritis; Schnitzler Syndrome; Depressive Disorder, Major; Polyarticular Juvenile Idiopathic Arthritis; Non-radiographic axial spondyloarthritis; Uveitis	Details
Tocilizumab biosimilar (Bio-Thera Solutions)	BAT-1806; BIIB-800	Approved	Bio-Thera Solutions Ltd	施瑞立, TOFIDENCE	Mainland China	Arthritis, Rheumatoid; Arthritis, Juvenile; Cytokine Release Syndrome	Bio-Thera Solutions Ltd	2023-01-16	Cytokine Release Syndrome; Polyarticular Juvenile Idiopathic Arthritis; Arthritis, Rheumatoid; Arthritis, Juvenile	Details
Sarilumab	SAR-153191; REGN-88	Approved	Sanofi	Kevzara	United States	Arthritis, Rheumatoid	Sanofi-Synthelabo	2017-05-22	Non-radiographic axial spondyloarthritis; Arthritis, Rheumatoid; Coronavirus Disease 2019 (COVID-19); Sarcoidosis; Mastocytosis, Systemic; Arthritis, Juvenile; Polymyalgia Rheumatica; Severe Acute Respiratory Syndrome; Uveitis	Details
Tocilizumab biosimilar (Livzon Group)	LZM-008	Approved	Livzon Pharmaceutical Group Inc	安维泰	Mainland China	Arthritis, Rheumatoid	Livzon Mabpharm Inc	2023-01-18	Arthritis, Rheumatoid	Details
Tocilizumab biosimilar (Fresenius kabi)	MSB-11456	Approved	Merck Serono	Tyenne®	EU	Cytokine Release Syndrome; Arthritis, Rheumatoid; Giant Cell Arteritis; Coronavirus Disease 2019 (COVID-19)	Fresenius Kabi Deutschland Gmbh	2023-09-15	Cytokine Release Syndrome; Giant Cell Arteritis; Polyarticular Juvenile Idiopathic Arthritis; Arthritis, Rheumatoid; Coronavirus Disease 2019 (COVID-19)	Details