Glycoprotein D (HSV-1)

Glycoprotein D (HSV-1) Informations sur la molécule

Nom anglais	Envelope glycoprotein D	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1	Alias de la cible
Phase de R&D la plus avancée	Phase 2 Clinical

Nom anglais	Envelope glycoprotein D
Alias de la cible
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1
Phase de R&D la plus avancée	Phase 2 Clinical

Demande de produit

Glycoprotein D (HSV-1)Contexte de la molécule

Herpesvirus infections are widely spread throughout the world population. Herpes simplex virus (HSV) belongs to the α-herpesvirus subfamily. There are two main types of HSV, HSV-1 and HSV-2, which infect humans. HSV-2 mainly causes genital lesions, whereas HSV-1 is involved in both oral and genital infections. Glycoprotein D (gD) is a structural component of the herpes simplex virus type 1 (HSV-1) envelope which is essential for virus entry and fusion with host cells. gD plays an important role by binding to the host receptors such as herpes virus entry mediator (HVEM) and nectin-1, a member of the immunoglobulin (Ig)-like cell adhesion molecules.