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Page d'accueilToutes les moléculesIL-23R
IL-23R
IL-23R Informations sur la molécule
| Nom anglais | Interleukin 23 Receptor | Nombre de médicaments commercialisés | 1 |
| Nombre de médicaments cliniques | 2 | Alias de la cible | IL-23 receptor，IL23R，Interleukin 23 Receptor，Interleukin-23 Receptor，IL-23R |
| Phase de R&D la plus avancée | Approved | ||
| Nom anglais | Interleukin 23 Receptor |
| Alias de la cible | IL-23 receptor，IL23R，Interleukin 23 Receptor，Interleukin-23 Receptor，IL-23R |
| Nombre de médicaments commercialisés | 1 |
| Nombre de médicaments cliniques | 2 |
| Phase de R&D la plus avancée | Approved |
Demande de produit
IL-23RContexte de la molécule
Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
IL-23RAlias de la molécule
IL-23 R,IL-23 Receptor
Informations sur les médicaments cliniques
| Nom anglais | Code de recherche | Phase de R&D | Entreprise | Indication | Essai clinique |
|---|---|---|---|---|---|
| Bezisterim | HE-3286; NE-3107 | Phase 3 Clinical | Harbor Therapeutics Inc | Alzheimer Disease; Arthritis, Rheumatoid; Brain Injuries, Traumatic; Colitis, Ulcerative; Diabetes Mellitus, Type 2; Insulin Resistance; Parkinson Disease; Post-Acute COVID-19 Syndrome | Details |
| PN-232 | PN-232; JNJ75105186 | Phase 1 Clinical | Protagonist Therapeutics Inc | Details |
Informations sur les médicaments commercialisés
| Nom anglais | Code de recherche | Phase de R&D | Entreprise | Plus ancien nom de marque | Pays d'approbation le plus ancien | Indication la plus ancienne | Société d'approbation la plus ancienne | Date d'approbation la plus ancienne | Indication | Essai clinique |
|---|---|---|---|---|---|---|---|---|---|---|
| Icotrokinra | PN-235; JNJ-2113; JNJ-77242113-AAC; PN-21235; JNJ-77242113 | Approved | Protagonist Therapeutics Inc | ICOTYDE | United States | Plaque psoriasis | Janssen Biotech Inc | 2026-03-17 | Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Erythrodermic psoriasis; Generalised pustular psoriasis; Plaque psoriasis; Psoriasis | Details |
- Informations sur la molécule
- Demande de produit
- Informations sur les médicaments commercialisés
- Informations sur les médicaments cliniques
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