Xanthine dehydrogenase Informations sur la molécule
Molecule Name
Xanthine dehydrogenase
Alias de la molécule
XAN1, XO, XOR
Drug Development Progress
Nombre de médicaments cliniques7
Nombre de médicaments commercialisés5
Phase de R&D la plus avancéeApproved
Alias de la cible
XD，XDH，Xanthine Dehydrogenase，Xanthene Dehydrogenase，XAN1，XDHA，XOR，Xanthine oxidase，EC 1.7.2.2，EC:1.17.3.2，EC 1.17.1.4，EC:1.17.1.4，XO，Xanthine oxidoreductase，Xanthine dehydrogenase/oxidase
Demande de produit
Informations sur les médicaments cliniques
| Nom anglais | Code de recherche | Phase de R&D | Entreprise | Indication | Essai clinique |
|---|---|---|---|---|---|
| Tigulixostat | LC-350189; IBI-350; LR-19074 | Phase 3 Clinical | Lg Chemical Ltd | Hyperuricemia; Heart Diseases; Gout | Details |
| Oxipurinol （XORTX Therapeutics） | XRx-008; XRx-101 | Phase 2 Clinical | Xortx Therapeutics | Polycystic Kidney Diseases | Details |
| IBI-128 | IBI128; IBI-128 | Phase 2 Clinical | Innovent Biologics(Suzhou) Co Ltd | Hyperuricemia; Metabolic Diseases; Arthritis, Gouty; Gout | Details |
| THDBH-151 | THDBH151; THDBH-151; [14C]THDBH151 | Phase 2 Clinical | Dongbao Zixing (Hangzhou) Biological Medicine Co Ltd | Gout | Details |
| Xrx-221 | Phase 1 Clinical | Xortx Therapeutics | Diabetic Nephropathies | Details | |
| HZN-457 | HZN-457 | Phase 1 Clinical | Horizon Therapeutics Ireland Dac | Details | |
| HEC-93077 | HEC-93077; HEC93077 | Phase 1 Clinical | Guangdong Dongyangguang Pharmaceutical Co Ltd | Hyperuricemia; Gout | Details |
Informations sur les médicaments commercialisés
| Nom anglais | Code de recherche | Phase de R&D | Entreprise | Plus ancien nom de marque | Pays d'approbation le plus ancien | Indication la plus ancienne | Société d'approbation la plus ancienne | Date d'approbation la plus ancienne | Indication | Essai clinique |
|---|---|---|---|---|---|---|---|---|---|---|
| Allopurinol | BW-56-158; ATH-008; NSC-1390 | Approved | Sebela Ireland Ltd | Lopurin, Zyloric, Zyloprim, 路必利 | United States | Gout; Hyperuricemia | Casper Pharma Llc | 1966-08-19 | Hand-Foot Syndrome; Hyperuricemia; Diabetes Mellitus, Type 2; Liver Cirrhosis; Angina Pectoris; Nephrolithiasis; Renal Insufficiency, Chronic; Inflammation; Gout | Details |
| Febuxostat | TMX-67; TEI-6720; TMX-67XR | Approved | Teijin Pharma | 风定宁, Uloric, 优立通, Adenuric, Febric, 瑞扬, Feburic, Febutaz | EU | Gout | Menarini International Operations Luxembourg Sa | 2008-04-21 | Hyperuricemia; Kidney Calculi; Pain; Renal Insufficiency; Angina Pectoris; Hypertension; Tumor Lysis Syndrome; Vascular Diseases; Cardiovascular Diseases; Colitis, Ulcerative; Gout; Kidney Failure, Chronic | Details |
| Allopurinol sodium | Approved | Mylan Nv | Aloprim | United States | Hyperuricemia; Gout | Mylan Institutional Inc | 1996-05-17 | Hyperuricemia; Gout; Leishmaniasis | Details | |
| Allopurinol/Benzbromarone | Approved | Hyperuricemia | Details | |||||||
| Topiroxostat | FYX-051; SK-0910 | Approved | Fuji Yakuhin Co Ltd | Uriadec, Topiloric | Japan | Hyperuricemia; Gout | Sanwa Kagaku Kenkyusho Co Ltd, Fuji Yakuhin Co Ltd | 2013-06-28 | Hyperuricemia; Diabetic Nephropathies; Gout | Details |