Monoclonal Anti-BCMA Antibody, Mouse IgG1 (AM43)

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BCA-M43-100ug
$310.00
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BCA-M43-1mg (500ug X 2)
$2,245.00
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BCA-M43
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Source

Monoclonal Anti-BCMA Antibody, Mouse IgG1 (AM43) is a recombinant mouse monoclonal antibody expressed in HEK293 cells.

Antibody Type

Recombinant Monoclonal

Clone

AM43

Isotype

Mouse IgG1, Kappa

Host Species

Mouse

Reactivity

Human

Immunogen

BCMA

Specificity

The product specifically targets the extracellular domain of human BCMA protein and inhibits the interaction between BCMA and BAFF (IC50 = 14.79 μg/mL), as well as BCMA and APRIL (IC50 = 17.03 μg/mL).

Application
Application
Recommended Use
ELISA
0.2-2 μg/mL

* Recommended dilutions are for reference only. Optimal working concentrations may vary depending on your consumables, reagents, and assay conditions. We recommend optimizing for your specific system. No warranty is made regarding performance at any specific dilution.

Cross Verification

Positive: Cross-reactive by ELISA with human, cynomolgus and mouse BCMA protein.

Purification

Protein A purified.

Concentration

Please refer to the Certificate of Analysis (CoA).

Form

Lyophilized

Formulation

Lyophilized from a 0.22 μm-filtered solution in Tris (pH 7.5) containing 100 mM Glycine, 25 mM Arginine and 150 mM NaCl, with trehalose as protectant.

Please contact us for customized product forms or formulations.

Reconstitution

Please refer to the Certificate of Analysis (CoA) for specific instructions.

Shipping

Lyophilized product is shipped at ambient temperature.

Storage

For long term storage, the product should be stored in a lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
Notices

Product Specific Notices: For research use only.

Background

Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.