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Recombinant Monoclonal Anti-CD45(LCA) Antibody, Rabbit (1C3) is a CD45(LCA) primary antibody for IHC application. Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
Host Species | Rabbit |
Isotype | Rabbit IgG, Rabbit Kappa |
Clone | 1C3 |
Application | IHC-P |
Dilution Ratio | 1: 500 - 1: 2000 |
Form | Liquid |
Clonality | Monoclonal |
Reactivity | Human |
Synonyms | PTPRC, CD45, GP180, LCA, T200 |
Concentration | 0.9~1.1 mg/ml |
Specificity | React with CD45(LCA) protein on the membrane of target cell/tissue |
Purification Tech | Protein A |
Preservation | PBS, BSA, Glycerol |
Shipped at 4°C, Blue Ice. Store at +4°C for 14 days. Store at -20°C for long term.
Avoid freeze / thaw cycle. Upon delivery aliquot.