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Product Details
Background
Recombinant Monoclonal Anti-Claudin-18.2 Antibody, Mouse (3B10) is a Claudin-18.2 primary antibody for IHC application. The Claudin-18.2 (CLDN 18.2) protein, an isoform of Claudin 18, a member of the tight junction protein family, is a highly selective biomarker with limited expression in normal tissues and often abnormal expression during the occurrence and development of various primary malignant tumors, such as gastric cancer/gastroesophageal junction (GC/GEJ) cancer, breast cancer, colon cancer, liver cancer, head and neck cancer, bronchial cancer and non-small-cell lung cancer. Claudin-18.2 participates in the proliferation, differentiation and migration of tumor cells. Recent studies have identified Claudin-18.2 expression as a potential specific marker for the diagnosis and treatment of these tumors.
Product Specifications
Host SpeciesMouseIsotypeMouse IgG1, Mouse KappaClone3B10ApplicationIHC-PDilution Ratio1: 500 - 1: 2000FormLiquidClonalityMonoclonalReactivityHumanSynonymsCLDN 18.2Concentration0.6~0.9 mg/mlSpecificityReact with Claudin 18.2 protein on the membrane of target cell/tissue; No cross reactivity with Claudin 18.1Purification TechProtein GPreservationPBS, 10% Trehalose (pH7.4)Experiment Protocol
Storage
Shipped at 4°C, Blue Ice. Store at +4°C for 14 days. Store at -20°C for long term.
Avoid freeze / thaw cycle. Upon delivery aliquot.ACRO Quality Management System
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Performance Data
Sample Staining Data
Immunohistochemical analysis of paraffin embedded human gastric cancer tissue labelled with HCS-S278 at 1:1000 dilution. Membranous staining on tumor cells is observed.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with LEICA BOND IHC staining protocol.
Immunohistochemical analysis of paraffin embedded human pancreatic cancer tissue labelled with HCS-S278 at 1:1000 dilution. Membranous staining on tumor cells is observed.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with LEICA BOND IHC staining protocol.
Immunohistochemical analysis of paraffin embedded human colorectal cancer tissue labelled with HCS-S278 at 1:1000 dilution. Membranous staining on tumor cells is observed.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with LEICA BOND IHC staining protocol.
Immunohistochemical analysis of paraffin embedded human stomach tissue labelled with HCS-S278 at 1:1000 dilution, demonstrating postive staining.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with LEICA BOND IHC staining protocol.
Immunohistochemical analysis of paraffin embedded human lung tissue labelled with HCS-S278 at 1:1000 dilution, demonstrating negative staining, which indicating no reactivity with Claudin 18.1 protein in the tissue level.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with LEICA BOND IHC staining protocol.
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Drug Development Progress- English Name：
Claudin-18 splice variant 2
- Category：
- Approved Drugs：
1 Details
- Drugs in Clinical Trials：
82 Details
- Highest Development Stage：
Approved
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