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ADC lsotype Control Human IgG1 (MMAE)

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Availability
Qté
DNP-B904P1-100ug
$195.00
In Stock - Delivery in 2-3 business days
DNP-B904P1-1mg (500ug X 2)
$790.00
In Stock - Delivery in 2-3 business days
Total des articles Montant du produit$ 0

Détails du produit

  • Source

    ADC lsotype Control Human IgG1 (MMAE) (DNP-B904P1) is a chimeric monoclonal antibody recombinantly expressed in HEK293 cells, which combines the variable regions of a mouse monoclonal antibody with Human IgG1 constant domains.

  • Antibody Type

    Recombinant Monoclonal

  • Clone

    AM2

  • Isotype

    Human IgG1, Kappa

  • Host Species

    Mouse

  • DAR

    4

  • Purification

    Protein A purified.

  • Aggregation

    Less than 10%, as determined by SEC-MALS.

  • Concentration

    Please refer to the Certificate of Analysis (CoA).

  • Form

    Lyophilized

  • Formulation

    Lyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4), with trehalose as protectant.

    Please contact us for customized product forms or formulations.

  • Reconstitution

    Please refer to the Certificate of Analysis (CoA) for specific instructions.

  • Shipping

    Lyophilized product is shipped at ambient temperature.

  • Storage

    For long term storage, the product should be stored in a lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Notices

    Product Specific Notices: For research use only.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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FAQ

  • product

    Can lyophilized proteins remain stable during room-temperature shipping or temporary room-temperature exposure?

    In general, lyophilized proteins remain stable during room-temperature shipping or temporary exposure to room-temperature conditions.


    Many ACROBiosystems recombinant proteins are supplied in lyophilized (freeze-dried) form. The lyophilization process effectively removes moisture from the product, helping reduce degradation-related reactions and improve protein stability during transportation and storage.


    To evaluate the stability of lyophilized proteins under normal temperature conditions, ACROBiosystems conducted a stability study on 11 representative lyophilized protein products at 37°C. The study demonstrated that these proteins maintained good quality stability after storage at 37°C for approximately 20 days. Based on these validation results, temporary room-temperature exposure during shipping or handling is generally not expected to have a significant impact on product quality or downstream application performance.


    To ensure optimal long-term stability, products should be stored according to the storage conditions specified in the product Certificate of Analysis (COA) upon receipt.


    Supporting Document


Introduction de fond

MMAE (Monomethyl auristatin E) is a synthetic microtubule inhibitor. It binds to tubulin to prevent microtubule polymerization, inducing tumor cell cycle arrest and apoptosis. As a highly toxic payload commonly used in ADCs, it has excellent plasma stability; when conjugated to antibodies, it can precisely kill target cells and is widely applied in the R&D of ADC drugs for hematological malignancies and solid tumors.

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