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Détails du produit
Source
Chimeric Monoclonal Anti-Human IgG Fc Antibody, Mouse IgG1 (6F11C8) is recombinantly expressed in CHO. It consists of mouse variable regions genetically fused to mouse IgG1 constant domains.
Antibody Type
Recombinant Monoclonal
Clone
6F11C8
Isotype
Mouse IgG1, Kappa
Host Species
Mouse
Reactivity
Human IgG Fc, including IgG1–IgG4 isotypes and Fc-engineered variants (e.g. N297A, LALA, YTE, LS, S239D/I332E)
Immunogen
Recombinant Human Fc derived from CHO cells
Specificity
Specifically binds to the Fc region of human IgG without recognizing Fab fragments or mouse IgG isotypes.
Application
ApplicationRecommended Use / PerformanceELISA0.2-2 μg/mLCross Verification
Positive: Cross-reactive by ELISA with human IgG subclasses (IgG1, IgG2, IgG3, IgG4) and a panel of Fc-engineered variants including N297A, LALA, YTE, LS, S239D/I332E. Weak cross-reactivity by ELISA with cynomolgus IgG.
Negative: No detectable cross-reactivity by ELISA with mouse IgG subclasses (IgG1, IgG2a, IgG2b).Purification
Protein A purified.
Aggregation
Less than 10%, as determined by SEC-MALS.
Concentration
Please refer to the Certificate of Analysis (CoA).
Form
Lyophilized
Formulation
Lyophilized from a 0.22 μm-filtered solution in PBS, with trehalose as protectant.
Please contact us for customized product forms or formulations.
Reconstitution
Please refer to the Certificate of Analysis (CoA) for specific instructions.
Shipping
Lyophilized product is shipped at ambient temperature.
Storage
For long term storage, the product should be stored in a lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
Notices
Product Specific Notices: For research use only.
ACRO Quality Management System
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Affichage des données
Bioactivity-ELISA
Immobilized Monoclonal Anti-SARS-CoV-2 Spike RBD Antibody, Human IgG4 (337L) (Cat. No. SPD-M402a) at 2μg/mL (100μL/well) can bind Monoclonal Anti-Human IgG Fc Antibody, Mouse IgG1 (6F11C8) (Cat. No. IGG-S307) with a linear range of 0.05-3.13 ng/mL (QC tested).
Protocol
Immobilized human IgG1, IgG2, IgG3 and IgG4 Fc bind monoclona anti-human IgG Fc antibody, mouse IgG1 (6F11C8). The antibody does not bind human IgA1 Fc or His-tag (Routinely tested).
Protocol
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FAQ
- product
Can lyophilized proteins remain stable during room-temperature shipping or temporary room-temperature exposure?
In general, lyophilized proteins remain stable during room-temperature shipping or temporary exposure to room-temperature conditions.
Many ACROBiosystems recombinant proteins are supplied in lyophilized (freeze-dried) form. The lyophilization process effectively removes moisture from the product, helping reduce degradation-related reactions and improve protein stability during transportation and storage.
To evaluate the stability of lyophilized proteins under normal temperature conditions, ACROBiosystems conducted a stability study on 11 representative lyophilized protein products at 37°C. The study demonstrated that these proteins maintained good quality stability after storage at 37°C for approximately 20 days. Based on these validation results, temporary room-temperature exposure during shipping or handling is generally not expected to have a significant impact on product quality or downstream application performance.
To ensure optimal long-term stability, products should be stored according to the storage conditions specified in the product Certificate of Analysis (COA) upon receipt.
Supporting Document
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