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Polyclonal NG2/Cspg4 Antibody, Rabbit IgG

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NG4-S455-20ul
$80.00
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NG4-S455-100ul
$415.00
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NG4-S455
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Source

Polyclonal NG2/Cspg4 Antibody, Rabbit IgG is a polyclonal antibody purified from rabbit serum.
Gene Synonyms: Cspg4, NG2, chondroitin sulfate proteoglycan 4, MCSP, MCSPG, Cspa, Cspg4a; 4732461B14Rik.

Antibody Type

Polyclonal Antibody

Clone

AS455

Isotype

Rabbit IgG, Kappa

Host Species

Rabbit

Reactivity

Rabbit

Immunogen

The extracellular fragment of mouse CSPG4

Specificity

Antigen retrieval is required for brighter signal before immunostaining. This antibody may not be suitable for IF staining on brain sections from animals older than P7.

Application
Application
Recommended Use
IF
1:200

* Recommended dilutions are for reference only. Optimal working concentrations may vary depending on your consumables, reagents, and assay conditions. We recommend optimizing for your specific system. No warranty is made regarding performance at any specific dilution.

Purification

Protein A purified.

Concentration

Please refer to the Certificate of Analysis (CoA).

Form

Liquid

Formulation

Supplied a 0.22 μm-filtered solution in PBS (pH 7.4) containing 50 Mm Glycine and 65 mM Tris, with 40% glycerol as protectant.

Please contact us for customized product forms or formulations.

Storage

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • Shipped at -20°C. Store at -70°C for 12 months.
Notices

Product Specific Notices: For research use only.

ACRO Quality Management System

Introduction de fond

Neuron-glial antigen 2 (NG2), also known as chondroitin sulphate proteoglycan 4 (CSPG4), is a surface type I transmembrane core proteoglycan that is crucially involved in cell survival, migration and angiogenesis. In the central nervous system, NG2/Cspg4 is expressed in certain glia cells which are sometimes called polydendrocytes or oligodendrocyte precursor cells (OPCs), as well as in mesenchymal stem cells, osteoblasts, melanocytes, smooth muscle cells and macrophages. NG2/Cspg4-mediated signaling has been shown to play an important role in the progression of several tumor types including glioblastoma and malignant melanoma. NG2/Cspg4 is also a typical marker for vessel-surrounding pericytes, which contribute to the stabilization of microvessels, the regulation of capillary blood flow and angiogenesis.

Ampofo E, et al. Cell Mol Biol Lett. 2017;22:4. doi: 10.1186/s11658-017-0035-3.

General Notes: FOR RESEARCH USE ONLY.