CHO/Human TSHR Stable Cell Line

• Genetically modified cell lines best reflect MOA (Mechanism of Action)
• Higher activity and larger assay window for robust and reproducible cell-based bioassay
• Comprehensive application data to support assay development and validation
• Full tracible record, stringent quality control and validated cell passage stability
• Parental cell line legally obtained from internationally recognized cell resource bank and commercially licensed
• Global commercial license assistance whenever regulatory filing is required

The CHO/Human TSHR Stable Cell Line was engineered to express the full length human TSHR (Uniprot: P16473-1). Surface expression of human TSHR was confirmed by flow cytometry.

• Useful for cell-based TSHR binding assay

• Screen for human TSHR agonists based on cAMP accumulation assay

Adherent

Hygromycin B (20 μg/mL)

F-12K + 10% FBS

Serum-free cell cryopreservation medium

1 vial contains at least 5×10^6 cells in 1 mL serum-free cryopreservation medium

Frozen in liquid nitrogen.

Negative

Negative

See data sheet for detailed culturing and assay protocol.