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Human AGO1 Protein, His Tag (MALS verified)

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AG1-H5543-100ug
$380.00
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AG1-H5543-1mg
$2,600.00
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AG1-H5543
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Product Details
Performance Data
Reviews & Citations
Resources
  • Product Details
  • Performance Data
  • Reviews & Citations
  • Important Statement
  • Resources
Synonyms

AGO1

Source

Human AGO1 Protein, His Tag (AG1-H5543) is expressed from Baculovirus-Insect cells. It contains AA Glu 2 - Ala 857 (Accession # Q9UL18-1).

Predicted N-terminus: Met

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 99.1 kDa. The protein migrates as 95-120 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

Formulation

Supplied as 0.2 μm filtered solution in PBS, pH7.4 with glycerol as protectant.

Contact us for customized product form or formulation.

Shipping and Storage

This product is supplied and shipped on dry ice.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • The product MUST be stored at -70°C or lower upon receipt;
  • -70°C for 3 months under sterile conditions.
ACRO Quality Management System

Background

AGO1 (Argonaute-1) is a key protein in the RNA interference (RNAi) pathway. As a core component of the RNA-induced silencing complex (RISC), it binds to small non-coding RNAs like microRNAs (miRNAs) and short interfering RNAs (siRNAs). Unlike its close relative AGO2, AGO1 lacks the slicer activity to cleave target messenger RNAs (mRNAs). Instead, its primary function is to guide RISC to target mRNAs, leading to translational repression and subsequent mRNA degradation. This makes AGO1 crucial for gene silencing and the post-transcriptional regulation of gene expression.