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Mouse Cadherin-3 Protein, His Tag

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Numéro de produit/spécification
Prix
Qté
CA3-M52H3-100ug
$410.00
CA3-M52H3-1mg
$2625.00
ETA of in-stock products:2 business days
Total des articles Montant du produit$ 0

Détails du produit

  • Synonyms

    CDH3, CDHP, Cadherin-3, P-cadherin

  • Source

    Mouse Cadherin-3 Protein, His Tag (CA3-M52H3) is expressed from human 293 cells (HEK293). It contains AA Glu 100 - Gly 647 (Accession # P10287).

    Predicted N-terminus: Glu 100

    Request for sequence
  • Molecular Characterization

    Cadherin-3 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 62.3 kDa. The protein migrates as 53-55 kDa and 70-80 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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  • SDS-PAGE

    Cadherin-3 SDS-PAGE

    Mouse Cadherin-3 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

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Introduction de fond

Cadherin-3 (CDH3), also known as P-Cadherin, is a classical cadherin that functions as a calcium-dependent glycoprotein mediating cell-cell adhesion. Structurally, it is characterized by five extracellular cadherin repeats, a single transmembrane domain, and a highly conserved cytoplasmic tail. The CDH3 gene resides within a cadherin cluster on chromosome 16q, a genomic region linked to loss of heterozygosity in breast and prostate cancer. Furthermore, aberrant expression of the protein is implicated in the pathology of cervical adenocarcinoma.

Progrès de frontière

 
Progrès du développement médicamenteux
  • Nom anglais:

    Cadherin 3

  • Catégorie:

  • Nombre de médicaments répertoriés:

    0 Détails

  • Nombre de médicaments cliniques:

    7 Détails

  • Étape de développement la plus élevée:

    Phase 2 Clinical

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