Cynomolgus / Rhesus macaque Cadherin-6 / KCAD / CDH6 Protein, Fc Tag (MALS verified)

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Cat. No. / Size
Price
Qty
CA6-C5253-100ug
$290.00
CA6-C5253-1mg (200ug X 5)
$1800.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    CDH6, CAD6, KCAD, K-cadherin, Cadherin-6

  • Source

    Cynomolgus / Rhesus macaque Cadherin-6 Protein, Fc Tag (CA6-C5253) is expressed from human 293 cells (HEK293). It contains AA Thr 22 - Gly 614 (Accession # G7MUQ7-1). In the region Thr 22 - Gly 614, the amino acid sequences of Cynomolgus and Rhesus macaque Cadherin-6 are identical.

    Predicted N-terminus: Thr 22

    Request for sequence
  • Molecular Characterization

    Cadherin-6 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 92.5 kDa. The protein migrates as 110-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    Cadherin-6 SDS-PAGE

    Cynomolgus / Rhesus macaque Cadherin-6 Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    Cadherin-6 SEC-MALS

    The purity of Cynomolgus / Rhesus macaque Cadherin-6 Protein, Fc Tag (Cat. No. CA6-C5253) is more than 90% and the molecular weight of this protein is around 185-220 kDa verified by SEC-MALS.

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Background

Cadherin-6 (CDH6) is also known as Kidney cadherin (K-cadherin or KCAD), is a a type II classical cadherin from the cadherin superfamily. Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH6 / KCAD contains five cadherin domains. CDH6 is highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression and also expressed in certain liver and kidney carcinomas.

Recent Advances

 
Drug Development Progress
  • English Name:

    Cadherin-6

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    5 Details

  • Highest Development Stage:

    Phase 3 Clinical

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