Human CCR2 Full Length Protein (VLP)

AIDD‑Ready
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CC2-H52P3-20ug
$620.00
In Stock - Delivery in 1-2 business days
CC2-H52P3-100ug
$1,235.00
In Stock - Delivery in 1-2 business days
CC2-H52P3-500ug (250ug X 2)
$4,305.00
In Stock - Delivery in 2-3 weeks
CC2-H52P3
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  • Détails du produit
  • Affichage des données
  • Reviews & Citations
  • Important Statement
  • Resources
Application
  • Immunization
  • Cell based assay (FACS or functional assay)
  • Screening (ELISA)
Synonyms

C-C chemokine receptor type 2, C-C CKR-2, CC-CKR-2, CC-CKR-2CKR2B, CCR2, CCR-2, CCR2A, CCR2B, CD192 antigen, CD192, chemokine (C-C motif) receptor 2, CKR2, CKR2A, CMKBR2, CMKBR2MGC111760, FLJ78302, MCP-1 receptor, MCP-1-R, MCP-1-RMGC103828, MGC168006, Monocyte chemoattractant protein 1 receptor, monocyte chemotactic protein 1 receptor

Source

Human CCR2 Full Length Protein (VLP) (CC2-H52P3) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Leu 360 (Accession # P41597-2).

Predicted N-terminus: Met 1

Molecular Characterization

*The isotype control of empty/mock VLP (Cat. No. VLP-N5213) is sold separately and not included in protein, you can follow the link for product information.

Structure

Virus-like particles (VLPs) are protein particles that mimic the shape of viruses but lack a viral genome, and incorporating transmembrane proteins on the external surface.

Synthesis Process

Envelope virus-like particles (eVLPs) are produced by co-expressing target membrane proteins with viral structural proteins in mammalian cells, enabling native embedding of membrane proteins into the lipid bilayer during VLP budding. This approach preserves authentic conformation, post-translational modifications, and orientation, while creating a completely detergent-free environment with repetitive multivalent display and strong immunogenicity making them ideal for immunization, binding assays in antibody discovery and screening (ELISA), and cell-based assays such as FACS, etc.

Endotoxin

Less than 1.0 EU per μg by the LAL method / rFC method.

Formulation

The VLPs are highly immunogenic, so the immunization strategy should be optimized (antigen dose, regimen and adjuvant).

Supplied as 0.2 μm filtered solution in PBS, pH7.4 with glycerol as protectant.

Contact us for customized product form or formulation.

Shipping and Storage

This product is supplied and shipped on dry ice.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • The product MUST be stored at -70°C or lower upon receipt;
  • -70°C for 12 months under sterile conditions.

Introduction de fond

The primary receptor for CCL2 (MCP-1), a major chemokine driving monocyte egress from bone marrow and recruitment to inflamed tissues. The CCR2-CCL2 axis promotes tumor-associated macrophage (TAM) accumulation and fibrosis. Antagonists aim to reprogram the immunosuppressive tumor stroma and treat inflammatory diseases.