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Biotinylated Cynomolgus CD6 Protein, His,Avitag™ (MALS verified)

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Numéro de produit/spécification
Prix
Qté
CD6-C82E3-100ug
$360.00
CD6-C82E3-1mg (200ug X 5)
$2615.00
ETA of in-stock products:2 business days
Total des articles Montant du produit$ 0

Détails du produit

  • Synonyms

    CD6, TP120, T12

  • Source

    Biotinylated Cynomolgus CD6 Protein, His,Avitag (CD6-C82E3) is expressed from human 293 cells (HEK293). It contains AA His 18 - Leu 399 (Accession # XP_005577746.1).

    Predicted N-terminus: His 18

    Request for sequence
  • Molecular Characterization

    CD6 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™).

    The protein has a calculated MW of 44.4 kDa. The protein migrates as 63-90 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Labeling

    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

  • Protein Ratio

    Passed as determined by the HABA assay / binding ELISA.

  • Purity

    >90% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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  • SDS-PAGE

    CD6 SDS-PAGE

    Biotinylated Cynomolgus CD6 Protein, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    CD6 SEC-MALS

    The purity of Biotinylated Cynomolgus CD6 Protein, His,Avitag (Cat. No. CD6-C82E3) is more than 95% and the molecular weight of this protein is around 70-90 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     CD6 ELISA

    Immobilized Biotinylated Cynomolgus CD6 Protein, His,Avitag (Cat. No. CD6-C82E3) at 1 μg/mL (100 μL/well) on streptavidin precoated (0.5 μg/well) plate can bind Human ALCAM, Fc Tag (Cat. No. CD6-H5259) with a linear range of 0.3-2 ng/mL (QC tested).

    Protocol
  •  CD6 ELISA

    Immobilized Human ALCAM, Fc Tag (Cat. No. CD6-H5259) at 5 μg/mL (100 μL/well) can bind Biotinylated Cynomolgus CD6 Protein, His,Avitag (Cat. No. CD6-C82E3) with a linear range of 0.01-0.313 μg/mL (Routinely tested).

    Protocol
  •  CD6 ELISA

    Immobilized Human ALCAM, His Tag (Cat. No. CD6-H5228) at 5 μg/mL (100 μL/well) can bind Biotinylated Cynomolgus CD6 Protein, His,Avitag (Cat. No. CD6-C82E3) with a linear range of 0.01-0.625 μg/mL (Routinely tested).

    Protocol

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Introduction de fond

CD6 (Cluster of Differentiation 6) is a transmembrane protein primarily expressed on T-lymphocytes and certain other immune cells. Structurally, it is characterized by three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule (ALCAM). Functionally, CD6 is critical for the continuation of T cell activation and exhibits scavenger receptor activity. Aberrant CD6 function is associated with diseases such as Multiple Sclerosis. Its paralog is DMBT1.

Progrès de frontière

 
Progrès du développement médicamenteux
  • Nom anglais:

    T-cell differentiation antigen CD6

  • Catégorie:

  • Nombre de médicaments répertoriés:

    1 Détails

  • Nombre de médicaments cliniques:

    0 Détails

  • Étape de développement la plus élevée:

    Approved

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