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Human CNTF Protein, premium grade

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Numéro de produit/spécification
Prix
Qté
CNF-H5114-20ug
$200.00
CNF-H5114-50ug
$305.00
CNF-H5114-500ug
$1505.00
ETA of in-stock products:2 business days
Total des articles Montant du produit$ 0

Détails du produit

  • Synonyms

    CNTF, HCNTF, Ciliary neurotrophic factor

  • Source

    Human CNTF Protein, premium grade (CNF-H5114) is expressed from E. coli cells. It contains AA Ala 2 - Met 200 (Accession # P26441-1).

    Predicted N-terminus: Met

    It is produced under our rigorous quality control system that incorporates a comprehensive set of tests including sterility and endotoxin tests. Product performance is carefully validated and tested for compatibility for cell culture use or any other applications in the early preclinical stage. When ready to transition into later clinical phases, we also offer a custom GMP protein service that tailors to your needs. We will work with you to customize and develop a GMP-grade product in accordance with your requests that also meets the requirements for raw and ancillary materials use in cell manufacturing of cell-based therapies.

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  • Molecular Characterization

    CNTF Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries no "tag".

    The protein has a calculated MW of 22.9 kDa. The protein migrates as 26-27 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Sterility

    Negative

  • Mycoplasma

    Negative

  • Purity

    >90% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH8.0 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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  • SDS-PAGE

    CNTF SDS-PAGE

    Human CNTF Protein, premium grade on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    CNTF SEC-MALS

    The purity of Human CNTF Protein, premium grade (Cat. No. CNF-H5114) is more than 95% and the molecular weight of this protein is around 17-27 kDa verified by SEC-MALS.

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  • M***i2025-05-13
    J'aime
    The Human CNTF Protein (Premium Grade) from ACROBiosystems is a recombinant ciliary neurotrophic factor designed to support neuroscience and cell therapy research. It offers high-quality, reliable option for researchers in neuroscience and related fields. Its stringent quality control, high purity, and stability make it a valuable reagent for various experimental applications.
  • G***R2025-05-07
    J'aime
    Acro Biosystems' BDNF recombinant protein stands out as a high-quality reagent for researchers investigating cortical projection neuron differentiation. Its consistent performance and positive impact on key developmental markers make it a valuable tool for both basic research and potential translational applications. We would confidently recommend this product to other labs working in this area.

Introduction de fond

Ciliary Neurotrophic Factor (CNTF) is a polypeptide hormone and neurotrophic factor whose actions have mainly been studied in the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neural populations including astrocytes. It is a hypothalamic neuropeptide that is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. In addition to the predominant monocistronic transcript originating from this locus, the gene is also cotranscribed with the upstream ZFP91 gene. Cotranscription from the two loci results in a transcript that contains a complete coding region for the zinc finger protein but lacks a complete coding region for ciliary neurotrophic factor.

Progrès de frontière

 
Progrès du développement médicamenteux
  • Nom anglais:

    Ciliary neurotrophic factor

  • Catégorie:

  • Nombre de médicaments répertoriés:

    0 Détails

  • Nombre de médicaments cliniques:

    0 Détails

  • Étape de développement la plus élevée:

    Preclinical

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