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Mouse E-Selectin Protein, His Tag, low endotoxin (MALS verified)

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CDE-M52H3-100ug
$260.00
In Stock - Delivery in 1-2 business days
CDE-M52H3-1mg
$1,750.00
In Stock - Delivery in 1-2 business days
CDE-M52H3
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Synonyms

SELE, RP1-117P20.2, CD62E, ELAM1, ESEL, LECAM2, E-Selectin

Source

Mouse E-Selectin Protein, His Tag (CDE-M52H3) is expressed from human 293 cells (HEK293). It contains AA Trp 22 - Arg 556 (Accession # Q00690).

Predicted N-terminus: Trp 22

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 60.3 kDa. The protein migrates as 80-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 0.01 EU per μg by the LAL method / rFC method.

Purity

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System

Introduction de fond

E-Selectin, a key member of the selectin family, is an adhesion molecule primarily expressed on vascular endothelial cells upon stimulation by pro-inflammatory cytokines like IL-1 and TNF-α. E-Selectin mediates the initial rolling of leukocytes on endothelium via recognizing sialyl Lewis X ligands, a critical step for leukocyte recruitment to inflamed tissues. It also participates in amplifying inflammatory responses and is implicated in pathological processes such as atherosclerosis and tumor metastasis. Its induced expression and ligand specificity make it a pivotal player in immune surveillance and inflammation.