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Détails du produit
Synonyms
FGFR1, BFGFR, CD331, CEK, FGFBR, FLG, HBGFR, N-SAM, FLT2, H2, KAL2, FLJ14326
Source
Human FGF R1, His Tag (FG1-H5223) is expressed from human 293 cells (HEK293). It contains AA Arg 22 - Ile 376 (Accession # P11362-7).
Predicted N-terminus: Arg 22
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 41.2 kDa. The protein migrates as 60-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 1.0 EU per μg by the LAL method / rFC method.
Purity
>95% as determined by SDS-PAGE.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Shipping and Storage
This product is shipped at ambient temperature.
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Affichage des données
SDS-PAGE
Human FGF R1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.
Bioactivity-SPR
Human FGF R1, His Tag (Cat. No. FG1-H5223) captured on CM5 chip via anti-His antibody can bind Human FGF acidic, Tag Free (Cat. No. AFF-H4116) with an affinity constant of 55.9 nM as determined in a SPR assay (Biacore 8K) (QC tested).
Protocol
Biotinylated Human FGF basic, Avitag,His Tag (Cat. No. FGC-H81E3) immobilized on SA Chip can bind Human FGF R1, His Tag (Cat. No. FG1-H5223) with an affinity constant of 96.3 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).
Protocol
Bioactivity-BLI
Loaded Biotinylated Human FGF-7, His,Avitag (Cat. No. FG7-H82E7) on SA Biosensor, can bind Human FGF R1, His Tag (Cat. No. FG1-H5223) with an affinity constant of 243 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
Protocol
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Introduction de fond
Progrès de frontière
Progrès du développement médicamenteux- Nom anglais：
Fibroblast growth factor receptor 1
- Catégorie：
- Nombre de médicaments répertoriés：
11 Détails
- Nombre de médicaments cliniques：
24 Détails
- Étape de développement la plus élevée：
Approved
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