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Human / Cynomolgus / Mouse / Rat GDF-8 Protein, Tag Free, low endotoxin

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GD8-H5344-50ug
$370.00
In Stock - Delivery in 1-2 business days
GD8-H5344-500ug
$2,470.00
In Stock - Delivery in 1-2 business days
GD8-H5344
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Product Details
Performance Data
Reviews & Citations
Resources
  • Product Details
  • Performance Data
  • Reviews & Citations
  • Important Statement
  • Resources
Synonyms

GDF-8, Myostatin, GDF8, MSTN, Growth, differentiation factor 8

Source

Human / Cynomolgus / Mouse / Rat GDF-8 Protein, Tag Free (GD8-H5344) is expressed from CHO cells. It contains AA Asp 267 - Ser 375 (Accession # O14793). In the region Asp 267 - Ser 375, the amino acid sequences of Human, Cynomolgus, Mouse and Rat GDF-8 are identical.

Predicted N-terminus: Asp 267

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries no "tag".

The protein has a calculated MW of 12.4 kDa. The protein migrates as 12.0 kDa under reducing (R) condition, and 11 kDa and 25 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 0.01 EU per μg by the LAL method / rFC method.

Purity

>90% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 50 mM HAC, pH3.0 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System

Background

Growth differentiation factor 8 (GDF8), also known as myostatin, is a unique member of the transforming growth factor-β superfamily that is expressed in human granulosa cells and has important roles in regulating a variety of ovarian functions. GDF8 acts as a negative regulator of skeletal muscle growth and differentiation. In addition to the expression in the musculoskeletal system, GDF8 is also expressed in various tissues, including the reproductive system.