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Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus) pre-Gc protein, His Tag (MALS verified)

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PRN-V52H4-50ug
$465.00
In Stock - Delivery in 1-2 business days
PRN-V52H4-100ug
$785.00
In Stock - Delivery in 1-2 business days
PRN-V52H4-1mg (500ug X 2)
$2,885.00
In Stock - Delivery in 1-2 business days
PRN-V52H4
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Synonyms

Glycoprotein C/Gc protein (HTNV)

Source

Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus) pre-Gc protein, His Tag (PRN-V52H4) is expressed from human 293 cells (HEK293). It contains AA Ser 649 - Asn 1105 (Accession # P08668).

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 52.5 kDa. The protein migrates as 54-60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 1.0 EU per μg by the LAL method / rFC method.

Purity

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, 0.5 M Arginine, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System

Introduction de fond

Hantaviruses (genus Orthohantavirus) are enveloped, negative-sense, single-stranded ribonucleic acid (RNA) viruses. The genomes of hantaviruses are composed of tri-segmented single-stranded, negative sense RNA, designated as small (S), medium (M) and large (L) segments. Each segment encodes nucleocapsid protein (NP), glycoprotein precursor (GPC) and RNA-dependent RNA polymerase (RdRp), respectively. GPC is posttranslationally cleaved into Gn and Gc. Glycoproteins Gn and Gc are transmembrane proteins and constitute an envelope with a lipid membrane derived from host cells. Gn and Gc are involved in receptor binding, membrane fusion and induction of protective immunity. The two glycoproteins are presumed to be the major elements involved in the induction of neutralizing antibodies during hantavirus infection.