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Mouse IL-2 R beta&IL-2 R gamma Heterodimer Protein, Fc Tag&Fc Tag (MALS verified)

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Numéro de produit/spécification
Prix
Qté
ILG-M5254-100ug
$360.00
ILG-M5254-1mg
$2615.00
ETA of in-stock products:2 business days
Total des articles Montant du produit$ 0

Détails du produit

  • Synonyms

    IL-2 R beta & IL-2 R gamma, IL-2RB & IL-2RG

  • Source

    Mouse IL-2RB&IL-2RG Heterodimer Protein, Fc Tag&Fc Tag (ILG-M5254) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Glu 240 (IL-2RB) & Trp 23 - Ala 263 (IL-2RG) (Accession # P16297-1 (IL-2RB) & P34902-1 (IL-2RG)).

    Predicted N-terminus: Ala 27 (IL-2RB) & Trp 23 (IL-2RG)

    Request for sequence
  • Molecular Characterization

    IL-2 R beta & IL-2 R gamma Structure

    Other Tags and Version Biotin & Other Labeled Version

    Mouse IL-2RB&IL-2RG Heterodimer Protein, Fc Tag&Fc Tag is produced by co-expression of IL-2RB and IL-2RG, has a calculated MW of 51.5 kDa (IL-2RB) and 54.5 kDa (IL-2RG). Subunit IL-2RB is fused with a human IgG1 Fc tag at the C-terminus and subunit IL-2RG is fused with a human IgG1 Fc tag at the C-terminus. The protein migrates as 65-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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  • SDS-PAGE

    IL-2 R beta & IL-2 R gamma SDS-PAGE

    Mouse IL-2RB&IL-2RG Heterodimer Protein, Fc Tag&Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    IL-2 R beta & IL-2 R gamma SEC-MALS

    The purity of Mouse IL-2RB&IL-2RG Heterodimer Protein, Fc Tag&Fc Tag (Cat. No. ILG-M5254) is more than 85% and the molecular weight of this protein is around 138-168 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     IL-2 R beta & IL-2 R gamma ELISA

    Immobilized Biotinylated Human IL-2, His,Avitag (Cat. No. IL2-H82E4) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Mouse IL-2RB&IL-2RG Heterodimer Protein, Fc Tag&Fc Tag (Cat. No. ILG-M5254) with a linear range of 0.008-0.25 μg/mL (QC tested).

    Protocol

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Introduction de fond

Both Interleukin-2 receptor subunit beta and Interleukin-2 receptor subunit gamma are receptor for interleukin-2. Common subunit for the receptors for a variety of interleukins. Interacts with SHB upon interleukin stimulation. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.

Progrès de frontière

 
Progrès du développement médicamenteux
  • Nom anglais:

    Interleukin-2 receptor subunit gamma

  • Catégorie:

  • Nombre de médicaments répertoriés:

    0 Détails

  • Nombre de médicaments cliniques:

    14 Détails

  • Étape de développement la plus élevée:

    Phase 2 Clinical

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