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Human IL-31 RA & OSMR Protein, Fc Tag (MALS verified)

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ILR-H525e-100ug
$410.00
In Stock - Delivery in 1-2 business days
ILR-H525e-1mg (500ug X 2)
$2,945.00
In Stock - Delivery in 1-2 business days
ILR-H525e
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Synonyms

IL-31 RA & OSMR

Source

Human IL-31 RA & OSMR Protein, Fc Tag (ILR-H525e) is expressed from human 293 cells (HEK293). It contains AA Ala 20 - Glu 519 (IL-31 RA) & Glu 28 - Met 740 (OSMR) (Accession # Q8NI17-1 & Q99650-1).

Predicted N-terminus: Ala 20

Molecular Characterization

Human IL-31 RA & OSMR Protein, Fc Tag, produced by co-expression of IL-31 RA and OSMR, has a calculated MW of 165.7 kDa. This protein carries a human IgG1 Fc tag at the C-terminus. The protein migrates as 200-250 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

The protein is designed as a heterodimer.

Endotoxin

Less than 1.0 EU per μg by the LAL method / rFC method.

Purity

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System

Introduction de fond

Interleukin-31 receptor subunit alpha is a protein that in humans is encoded by the IL31RA gene, also known as IL-31 receptor subunit alpha, IL-31RA, GLM-R, Gp130-like receptor, CRL3, GPL. Oncostatin M receptor (OSMR) and IL31RA form the heterodimeric receptor through which IL31 signals. IL31RA is a strong activator of STAT3 and STAT5, whereas STAT1 is only marginally tyrosine-phosphorylated. dditionally, demonstrate Jak1 binding to GPL and its activation in heteromeric complexes with the OSMR beta but also in a homomeric receptor complex.