user
menu
letter
Sign InRegister
langEnglisharrow

Mouse IL-4 R alpha & IL-13 R alpha 1 Protein, His Tag&His Tag (MALS & SPR verified)

AIDD‑Ready
Cat. No. / Size
Price
Availability
Qty
ILR-M52H8-100ug
$435.00
In Stock - Delivery in 1-2 business days
ILR-M52H8-1mg (500ug X 2)
$3,295.00
In Stock - Delivery in 2 weeks
ILR-M52H8
Sub-Total :
$ 0
Customize Product Request Quote
Contact Us
Contact Us
Sub-Total:
$ 0
Request Quote
Product Details
Performance Data
Reviews & Citations
Resources
  • Product Details
  • Performance Data
  • Reviews & Citations
  • Important Statement
  • Resources
Synonyms

IL-4 R alpha & IL-13 R alpha 1, IL4RA & IL13RA1

Source

Mouse IL-4 R alpha & IL-13 R alpha 1 Protein, His Tag&His Tag (ILR-M52H8) is expressed from human 293 cells (HEK293). It contains AA Ile 26 - Arg 233 & Ala 26 - Thr 340 (Accession # NP_001008700 & NP_598751.3).

Predicted N-terminus: Ile 26 & Ala 26

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

Mouse IL-4 R alpha & IL-13 R alpha 1 Protein, His Tag&His Tag, produced by co-expression of IL-4 R alpha and IL-13 R alpha 1, has a calculated MW of 29.6 kDa (IL-4 R alpha) and 41.2 kDa (IL-13 R alpha 1). Subunit IL-4 R alpha is fused with a polyhistidine tag at the C-terminus, and subunit IL-13 R alpha 1 contains a polyhistidine tag at the C-terminus. The protein migrates as 38-43 kDa and 55-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

The protein is designed as a heterodimer.

Purity

>90% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System

Background

Interleukin 4 Receptor (IL4R) also known as CD124, IL4Rα and BSF receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2-­biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R can alternatively associate with IL­13Ra1 to form the type II receptor which is responsive to both IL­4 and IL­13. Interleukin-4 receptor has been shown to interact with SHC1.