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Rat IL-4 R alpha & IL-13 R alpha 1 Protein, His Tag&His Tag (MALS & SPR verified)

AIDD‑Ready
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ILR-R52H5-100ug
$435.00
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ILR-R52H5-1mg (500ug X 2)
$3,295.00
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ILR-R52H5
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Synonyms

IL-4 R alpha & IL-13 R alpha 1, IL4RA & IL13RA1

Source

Rat IL-4 R alpha & IL-13 R alpha 1 Protein, His Tag&His Tag (ILR-R52H5) is expressed from human 293 cells (HEK293). It contains AA Ile 26 - Arg 232 & Thr 27 - Thr 342 (Accession # Q63257-1 & Q561K3).

Predicted N-terminus: Ile 26 & Thr 27

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

Rat IL-4 R alpha & IL-13 R alpha 1 Protein, His Tag&His Tag, produced by co-expression of IL-4 R alpha and IL-13 R alpha 1, has a calculated MW of 29.1 kDa (IL-4 R alpha) and 41 kDa (IL-13 R alpha 1). Subunit IL-4 R alpha is fused with a polyhistidine tag at the C-terminus, and subunit IL-13 R alpha 1 contains a polyhistidine tag at the C-terminus. The protein migrates as 43-53 kDa and 60-70 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

The protein is designed as a heterodimer.

Purity

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System

Introduction de fond

Interleukin 4 Receptor (IL4R) also known as CD124, IL4Rα and BSF receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2-­biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R can alternatively associate with IL­13Ra1 to form the type II receptor which is responsive to both IL­4 and IL­13. Interleukin-4 receptor has been shown to interact with SHC1.