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Cynomolgus Kallikrein 3 Protein, His Tag (active enzyme, MALS verified)

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KL3-C52H3-100ug
$368.00
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KL3-C52H3-1mg (500ug X 2)
$2,625.00
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KL3-C52H3
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Product Details
Performance Data
Reviews & Citations
Resources
  • Product Details
  • Performance Data
  • Reviews & Citations
  • Important Statement
  • Resources
Synonyms

KLK3, Kallikrein-3, APS, KLK2A1, PSA, Hk3, Seminin, Semenogelase

Source

Cynomolgus Kallikrein 3 Protein, His Tag (KL3-C52H3) is expressed from human 293 cells (HEK293). It contains AA Pro 19 - Pro 261 (Accession # Q6DT45).

Predicted N-terminus: Pro 19

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 28.7 kDa. The protein migrates as 30-35 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 1.0 EU per μg by the LAL method / rFC method.

Purity

>95% as determined by SDS-PAGE.

>95% as determined by SEC-MALS.

Formulation

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System

Background

Kallikrein-related peptidase 3, more commonly known as Kallikrein 3 (KLK3) or Prostate-Specific Antigen (PSA), is a serine protease belonging to the kallikrein family. Its primary function is to cleave proteins, and it is a key biomarker for prostate cancer. Secreted by the epithelial cells of the prostate gland, elevated levels of KLK3 in the blood are often indicative of prostate pathologies, including benign prostatic hyperplasia and prostate cancer. Beyond its role as a diagnostic marker, recent research explores its potential as a therapeutic target in cancer treatment. Its unique expression pattern and enzymatic function make it a subject of extensive research in oncology.