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Human Mesothelin / MSLN (296-580) Protein, Fc Tag (MALS verified)

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Numéro de produit/spécification
Prix
Qté
MSN-H526x-100ug
$335.00
MSN-H526x-1mg
$2105.00
ETA of in-stock products:2 business days
Total des articles Montant du produit$ 0

Détails du produit

  • Synonyms

    MSLN, Mesothelin, MPF

  • Source

    Human Mesothelin (296-580), Fc Tag (MSN-H526x) is expressed from human 293 cells (HEK293). It contains AA Glu 296 - Gly 580 (Accession # AAH09272).

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  • Molecular Characterization

    Mesothelin Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the N-terminus.

    The protein has a calculated MW of 59.1 kDa. The protein migrates as 60-68 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.1 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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  • SDS-PAGE

    Mesothelin SDS-PAGE

    Human Mesothelin (296-580), Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    Mesothelin SEC-MALS

    The purity of Human Mesothelin (296-580), Fc Tag (Cat. No. MSN-H526x) is more than 95% and the molecular weight of this protein is around 115-140 kDa verified by SEC-MALS.

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  • Bioactivity-ELISA

     Mesothelin ELISA

    Immobilized Human Mesothelin (296-580), Fc Tag (Cat. No. MSN-H526x) at 0.5 μg/mL (100 μL/well) can bind Anti-Human MSLN Mab with a linear range of 0.8-3 ng/mL (QC tested).

    Protocol

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Introduction de fond

Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.

Progrès de frontière

 
Progrès du développement médicamenteux
  • Nom anglais:

    Mesothelin

  • Catégorie:

  • Nombre de médicaments répertoriés:

    0 Détails

  • Nombre de médicaments cliniques:

    55 Détails

  • Étape de développement la plus élevée:

    Phase 2 Clinical

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