Human Nav1.6 Protein, Tag Free

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Cat. No. / Size
Price
Qty
NA6-H5113-100ug
$405.00
NA6-H5113-1mg
$2615.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    Nav1.6

  • Source

    Human Nav1.6 Protein, Tag Free (NA6-H5113) is expressed from E. coli cells. It contains AA Glu 1767 - Arg 1913 (Accession # Q9UQD0-1).

    Predicted N-terminus: Met

    Request for sequence
  • Molecular Characterization

    Nav1.6 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries no "tag".

    The protein has a calculated MW of 17.1 kDa. The protein migrates as 15-17 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH8.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    Nav1.6 SDS-PAGE

    Human Nav1.6 Protein, Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

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Background

Nav 1.6, encoded by the SCN8A gene, is a voltage-gated sodium channel highly concentrated at the axon initial segment and nodes of Ranvier. It plays a pivotal role in initiating action potentials and generating persistent currents. Gain-of-function mutations drive severe developmental epileptic encephalopathies, making Nav 1.6 a premier target for subtype-selective inhibitors. This product is focusing on C-terminus Truncation.

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