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Human Nectin-4 (32-153) Protein, His Tag (MALS verified)

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Numéro de produit/spécification
Prix
Qté
NE4-H5243-100ug
$415.00
NE4-H5243-1mg (500ug X 2)
$2625.00
ETA of in-stock products:2 business days
Total des articles Montant du produit$ 0

Détails du produit

  • Synonyms

    NECTIN4, LNIR, PRR4, PVRL4

  • Source

    Human Nectin-4 (32-153) Protein, His Tag (NE4-H5243) is expressed from human 293 cells (HEK293). It contains AA Gly 32 - Leu 153 (Accession # Q96NY8-1).

    Predicted N-terminus: His

    Request for sequence
  • Molecular Characterization

    Nectin-4 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 15.1 kDa. The protein migrates as 15-16 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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  • SDS-PAGE

    Nectin-4 SDS-PAGE

    Human Nectin-4 (32-153) Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    Nectin-4 SEC-MALS

    The purity of Human Nectin-4 (32-153) Protein, His Tag (Cat. No. NE4-H5243) is more than 90% and the molecular weight of this protein is around 15-20 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     Nectin-4 ELISA

    Immobilized Human Nectin-4 (32-153) Protein, His Tag (Cat. No. NE4-H5243) at 1 μg/mL (100 μL/well) can bind Mouse Anti-Nectin-4 Antibody with a linear range of 0.06-1 ng/mL (QC tested).

    Protocol

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Introduction de fond

Nectin-4(Nectin cell adhesion molecule 4) is a Nectin and nectin-like family of cell adhesion molecules. It is found in high levels in normal embryonic and fetal tissues, but decreases after adulthood and is limited in distribution in healthy tissues. Nectin-4 is overexpressed in a variety of tumor cells and promotes tumor cell growth and proliferation. Solid tumors with high expression of Nectin-4 include bladder cancer, pancreatic cancer, triple negative breast cancer, non-small cell lung cancer, stomach cancer, esophageal cancer, ovarian cancer and many other cancers. Studies have found that Nectin-4 promotes tumor cell proliferation, differentiation, migration and invasion by activating the PI3K/Akt pathway, and is believed to play an important role in the occurrence and metastasis of cancer. It is based on these research backgrounds that drug research targeting this target has emerged.

Progrès de frontière

 
Progrès du développement médicamenteux
  • Nom anglais:

    Nectin-4

  • Catégorie:

  • Nombre de médicaments répertoriés:

    1 Détails

  • Nombre de médicaments cliniques:

    28 Détails

  • Étape de développement la plus élevée:

    Approved

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