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Cynomolgus NPR1 / NPRA Protein, His Tag (MALS verified)

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Numéro de produit/spécification
Prix
Qté
NP1-C52H3-100ug
$385.00
NP1-C52H3-1mg
$2540.00
ETA of in-stock products:2 business days
Total des articles Montant du produit$ 0

Détails du produit

  • Synonyms

    Atrial natriuretic peptide receptor 1, NPR1, NPRA, GC-A, ANPRA, NPR-A

  • Source

    Cynomolgus NPR1 Protein, His Tag (NP1-C52H3) is expressed from human 293 cells (HEK293). It contains AA Gly 33 - Glu 473 (Accession # XP_005541810.1).

    Predicted N-terminus: Gly 33

  • Molecular Characterization

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 53.8 kDa. The protein migrates as 62-80 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

    The protein is designed as a dimer.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, 0.2 M Arginine, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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  • SDS-PAGE

    NPR1 SDS-PAGE

    Cynomolgus NPR1 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    NPR1 SEC-MALS

    The purity of Cynomolgus NPR1 Protein, His Tag (Cat. No. NP1-C52H3) is more than 85% and the molecular weight of this protein is around 125-155 kDa verified by SEC-MALS.

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Introduction de fond

Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.

Progrès de frontière

 
Progrès du développement médicamenteux
  • Nom anglais:

    Natriuretic peptide receptor 1

  • Catégorie:

  • Nombre de médicaments répertoriés:

    4 Détails

  • Nombre de médicaments cliniques:

    7 Détails

  • Étape de développement la plus élevée:

    Approved

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