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Product Details
Synonyms
OSM, MGC20461, Oncostatin M
Source
Human Oncostatin M (OSM) (26-221) Protein, premium grade (OSM-H5214) is expressed from human 293 cells (HEK293). It contains AA Ala 26 - Arg 221 (Accession # P13725).
Predicted N-terminus: Ala 26
It is produced under our rigorous quality control system that incorporates a comprehensive set of tests including sterility and endotoxin tests. Product performance is carefully validated and tested for compatibility for cell culture use or any other applications in the early preclinical stage. When ready to transition into later clinical phases, we also offer a custom GMP protein service that tailors to your needs. We will work with you to customize and develop a GMP-grade product in accordance with your requests that also meets the requirements for raw and ancillary materials use in cell manufacturing of cell-based therapies.
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries no "tag".
The protein has a calculated MW of 22.2 kDa. The protein migrates as 25-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 0.1 EU per μg by the LAL method / rFC method.
Sterility
Negative
Mycoplasma
Negative
Purity
>90% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System
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Performance Data
SDS-PAGE
Human Oncostatin M (OSM) (26-221) Protein, premium grade on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.
SEC-MALS
The purity of Human Oncostatin M (OSM) (26-221) Protein, premium grade (Cat. No. OSM-H5214) is more than 90% and the molecular weight of this protein is around 20-30 kDa verified by SEC-MALS.
Report
Bioactivity-Organoid Culture
iPSC derived liver organoids forming cystic structure of bile duct were cultured with Oncostatin M (Cat. No. OSM-H5214).
Bioactivity-SPR
Human LIF R Protein, Fc Tag (Cat. No. LIR-H4252) captured on Protein A Chip can bind Human Oncostatin M (OSM) (26-221) Protein, premium grade (Cat. No. OSM-H5214) with an affinity constant of 595 nM as determined in a SPR assay (Biacore 8K) (QC tested).
Protocol
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Background
Recent Advances
Drug Development Progress- English Name：
Oncostatin M
- Category：
- Approved Drugs：
0 Details
- Drugs in Clinical Trials：
0 Details
- Highest Development Stage：
Discontinued
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