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Biotinylated Human ROR2 / NTRKR2 Protein, His,Avitag™ (MALS verified)

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Numéro de produit/spécification
Prix
Qté
RO2-H82E3-25ug
$495.00
RO2-H82E3-200ug
$2140.00
ETA of in-stock products:2 business days
Total des articles Montant du produit$ 0

Détails du produit

  • Synonyms

    ROR2, NTRKR2

  • Source

    Biotinylated Human ROR2, His,Avitag (RO2-H82E3) is expressed from human 293 cells (HEK293). It contains AA Glu 34 - Gly 403 (Accession # A1L4F5-1).

    Predicted N-terminus: Glu 34

    Request for sequence
  • Molecular Characterization

    ROR2 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™).

    The protein has a calculated MW of 45.0 kDa. The protein migrates as 55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Labeling

    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

  • Protein Ratio

    Passed as determined by the HABA assay / binding ELISA.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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  • SDS-PAGE

    ROR2 SDS-PAGE

    Biotinylated Human ROR2, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    ROR2 SEC-MALS

    The purity of Biotinylated Human ROR2, His,Avitag (Cat. No. RO2-H82E3) is more than 85% and the molecular weight of this protein is around 50-80 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     ROR2 ELISA

    Immobilized Biotinylated Human ROR2, His,Avitag (Cat. No. RO2-H82E3) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-ROR2 Antibody, Human IgG1 with a linear range of 0.1-4 ng/mL (QC tested).

    Protocol

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Introduction de fond

Tyrosine-protein kinase transmembrane receptor ROR2 is also known as Neurotrophic tyrosine kinase, receptor-related 2 (NTRKR2), which belongs to the protein kinase superfamily and Tyr protein kinase family and ROR subfamily. ROR2 is a homodimer protein, which can binds YWHAB or interact with WTIP. ROR2 may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development.

Progrès de frontière

 
Progrès du développement médicamenteux
  • Nom anglais:

    Tyrosine-protein kinase transmembrane receptor ROR2

  • Catégorie:

  • Nombre de médicaments répertoriés:

    0 Détails

  • Nombre de médicaments cliniques:

    1 Détails

  • Étape de développement la plus élevée:

    Phase 2 Clinical

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