Human TIM-1 / HAVCR1 Protein, His Tag (MALS verified)

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Cat. No. / Size
Price
Qty
KI1-H52H3-100ug
$415.00
KI1-H52H3-1mg (500ug X 2)
$2615.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    HAVCR1, KIM1, TIM1, TIMD1

  • Source

    Human TIM-1 / HAVCR1, His Tag (KI1-H52H3) is expressed from human 293 cells (HEK293). It contains AA Ser 21 - Gly 295 (Accession # Q96D42-1).

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  • Molecular Characterization

    TIM-1 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 31.5 kDa. The protein migrates as 55-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    TIM-1 SDS-PAGE

    Human TIM-1 / HAVCR1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    TIM-1 SEC-MALS

    The purity of Human TIM-1 / HAVCR1, His Tag (Cat. No. KI1-H52H3) is more than 95% and the molecular weight of this protein is around 55-70 kDa verified by SEC-MALS.

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Background

Hepatitis A virus cellular receptor 1 is also known as HAVCR1, HAVCR, KIM1, TIM, TIM1, TIMD1, is widely expressed with highest levels in kidney and testis. The protein encoded by HAVCR1 gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Three transcript variants encoding the same protein have been found for this gene. HAVCR1 may play a role in T-helper cell development, the regulation of asthma and allergic diseases and in kidney injury and repair. In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus.

Recent Advances

 
Drug Development Progress
  • English Name:

    T-cell immunoglobulin mucin receptor 1

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

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  • Highest Development Stage:

    Discontinued

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