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Détails du produit
Synonyms
CD71, TFRC, TFR, sTfR, TfR1, Trfr, T9, p90
Source
Cynomolgus Transferrin R, His Tag (TFR-C524a) is expressed from human 293 cells (HEK293). It contains AA Cys 89 - Phe 760 (Accession # G8F602).
Predicted N-terminus: His
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 77.1 kDa. The protein migrates as 75-90 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
The protein is designed as a dimer.
Endotoxin
Less than 0.01 EU per μg by the LAL method / rFC method.
Purity
>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Shipping and Storage
This product is shipped at ambient temperature.
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Affichage des données
SDS-PAGE
Cynomolgus Transferrin R, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).
SEC-MALS
The purity of Cynomolgus Transferrin R, His Tag (Cat. No. TFR-C524a) is more than 90% and the molecular weight of this protein is around 145-175 kDa verified by SEC-MALS.
Report
Bioactivity-ELISA
Immobilized Cynomolgus Transferrin R, His Tag (Cat. No. TFR-C524a) at 5 μg/mL (100 μL/well) can bind Biotinylated Human Transferrin Protein, His,Avitag (Cat. No. TRN-H82E3) with a linear range of 0.06-2 ng/mL (QC tested).
Protocol
Bioactivity-SPR
Cynomolgus Transferrin R, His Tag (Cat. No. TFR-C524a) immobilized on CM5 Chip can bind Rhesus macaque Transferrin Protein, His Tag (Cat. No. TRN-R52H3) with an affinity constant of 4.09 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).
Protocol
Trontinemab captured on Protein A Chip can bind Cynomolgus Transferrin R, His Tag (Cat. No. TFR-C524a) with an affinity constant of 116 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).
Protocol
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Introduction de fond
Progrès de frontière
Progrès du développement médicamenteux- Nom anglais：
Transferrin receptor protein 1
- Catégorie：
- Nombre de médicaments répertoriés：
1 Détails
- Nombre de médicaments cliniques：
15 Détails
- Étape de développement la plus élevée：
Approved
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