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Détails du produit
Synonyms
uPAR, PLAUR, CD87, MO3
Source
Human uPAR, Fc Tag (UPR-H5254) is expressed from human 293 cells (HEK293). It contains AA Leu 23 - Arg 303 (Accession # Q03405-1).
Predicted N-terminus: Leu 23
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 57.8 kDa. The protein migrates as 65-90 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 0.1 EU per μg by the LAL method / rFC method.
Purity
>95% as determined by SDS-PAGE.
>95% as determined by SEC-MALS.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Shipping and Storage
This product is shipped at ambient temperature.
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System
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Affichage des données
SDS-PAGE
Human uPAR, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).
SEC-MALS
The purity of Human uPAR, Fc Tag (Cat. No. UPR-H5254) is more than 95% and the molecular weight of this protein is around 124-151 kDa verified by SEC-MALS.
Report
Bioactivity-ELISA
Immobilized Anti-uPAR Antibody, Mouse IgG1 at 1 μg/mL (100 μL/well) can bind Human uPAR, Fc Tag (Cat. No. UPR-H5254) with a linear range of 0.4-6 ng/mL (QC tested).
Protocol
Bioactivity-SPR
Human uPAR, Fc Tag (Cat. No. UPR-H5254) captured on Protein A Chip can bind Human PLAU / uPA Protein, His Tag (Cat. No. PLU-H5229) with an affinity constant of 10.6 pM as determined in SPR assay (Biacore 8K) (Routinely tested).
Protocol
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Introduction de fond
Progrès de frontière
Progrès du développement médicamenteux- Nom anglais：
Urokinase plasminogen activator surface receptor
- Catégorie：
- Nombre de médicaments répertoriés：
0 Détails
- Nombre de médicaments cliniques：
7 Détails
- Étape de développement la plus élevée：
Phase 3 Clinical
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