Activin RIB

Activin RIB Informations sur la molécule

Nom anglais	Transforming growth factor beta receptor 1	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	7	Alias de la cible	EC 2.7.11，TGF-beta type I receptor，Serine/threonine-protein kinase receptor R4，TGFBR1，Activin A receptor type II-like protein kinase of 53kD，Transforming Growth Factor Beta Receptor 1，Transforming Growth Factor-Beta Receptor Type I，Activin A Receptor Type II-Like Kinase， 53kDa，Activin Receptor-Like Kinase 5，TGFR-1，ALK-5，ALK5，SKR4，Mutant Transforming Growth Factor Beta Receptor I，TGF-Beta Receptor Type-1，TGF-Beta Receptor Type I，EC 2.7.11.30，ACVRLK4，LDS1A，LDS2A，AAT5，LDS1，TBRI，ESS1，MSSE，TbetaR-I，Transforming Growth Factor Beta Receptor I，Multiple Self-Healing Squamous Epithelioma，TBR-I，Receptor， Transforming Growth Factor-beta Type I，EC:2.7.11.30
Phase de R&D la plus avancée	Phase 3 Clinical

Nom anglais	Transforming growth factor beta receptor 1
Alias de la cible	EC 2.7.11，TGF-beta type I receptor，Serine/threonine-protein kinase receptor R4，TGFBR1，Activin A receptor type II-like protein kinase of 53kD，Transforming Growth Factor Beta Receptor 1，Transforming Growth Factor-Beta Receptor Type I，Activin A Receptor Type II-Like Kinase， 53kDa，Activin Receptor-Like Kinase 5，TGFR-1，ALK-5，ALK5，SKR4，Mutant Transforming Growth Factor Beta Receptor I，TGF-Beta Receptor Type-1，TGF-Beta Receptor Type I，EC 2.7.11.30，ACVRLK4，LDS1A，LDS2A，AAT5，LDS1，TBRI，ESS1，MSSE，TbetaR-I，Transforming Growth Factor Beta Receptor I，Multiple Self-Healing Squamous Epithelioma，TBR-I，Receptor， Transforming Growth Factor-beta Type I，EC:2.7.11.30
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	7
Phase de R&D la plus avancée	Phase 3 Clinical

Activin RIB Liste de produits

Attribut
Protein (1)
Bibliothèque de produits
En ligne (1)
Espèces
Human (1)
Étiquette
His Tag (1)
Marqueur
Unconjugated (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Structure protéique	Pureté	Caractéristiques	Pré-commande/Commande
ACB-H52H4	Human	HEK293	Human Activin RIB / ACVR1B Protein, His Tag				Ajouter au panier

Quantité totale1

Activin RIBContexte de la molécule

Activin receptor type-1B (ACVR1B) is also known as Activin receptor-like kinase 4 (ALK-4), Serine/threonine-protein kinase receptor R2 (SKR2), which belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. ACVR1B contains one GS domain and one protein kinase domain. The catalytic activity of ACVR1B is “ATP + [receptor-protein] = ADP + [receptor-protein] phosphate”. ACVR1B acts as a transducer of activin or activin like ligands (e.g., inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3. ACVR1B also transduces signals of nodal, GDF-1, and Vg1.

Activin RIBAlias de la molécule

ACVR1b,ALK4,ACVRLK4,ACTR-IB,SKR2

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
Galunisertib	LY-2157299	Phase 3 Clinical	Eli Lilly And Company	Amyotrophic Lateral Sclerosis; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colorectal Neoplasms; Glioblastoma; Glioma; Liver Neoplasms; Metastatic breast cancer; Myelodysplastic Syndromes; Nasopharyngeal Carcinoma; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Rectal Neoplasms; Solid tumours; Triple Negative Breast Neoplasms	Details
GF-101	GFH-018; GF-101; GFH018	Phase 2 Clinical	Genfleet Therapeutics (Shanghai) Co Ltd	Carcinoma, Non-Small-Cell Lung; Carcinoma, Transitional Cell; Liver Neoplasms; Pancreatic Neoplasms; Solid tumours	Details
Tosposertib phosphate	TU-2218; NCE401; NCE-401	Phase 2 Clinical	TiumBio Co Ltd	Idiopathic Pulmonary Fibrosis; Solid tumours	Details
Ontunisertib	ORG-129; AGMB-129	Phase 2 Clinical	Origo Biopharma Sociedad Litmitada	Crohn Disease	Details
TRK-250	TRK-250; BNC-1021	Phase 1 Clinical	Bonac Corp	Idiopathic Pulmonary Fibrosis	Details
Oxinseti	SH-3051	Phase 1 Clinical	Nanjing Sanhome Pharmaceutical Co Ltd	Liver Neoplasms; Solid tumours	Details
AGMB-447	AGMB-447; ORG-447	Phase 1 Clinical	AgomAb Therapeutics NV	Idiopathic Pulmonary Fibrosis	Details