ADORA2A Informations sur la molécule
Molecule Name
Adenosine A2a receptor
Alias de la molécule
ADORA2A,adenosine A2a receptor,A2aR, ADORA2, RDC8
Drug Development Progress
Nombre de médicaments cliniques23
Nombre de médicaments commercialisés53
Phase de R&D la plus avancéeApproved
Alias de la cible
Adenosine receptor A2a，ADORA2A，Adenosine A2a Receptor，ADORA2，Adenosine Receptor Subtype A2a，A2aR，RDC8，Receptor， Adenosine A2A
Contexte de la molécule
Adenosine Receptor Subtype A2a (ADORA2A) is a G-protein coupled adenosine receptor encoded by the ADORA2A gene. It is mainly involved in pathophysiological processes including neuroinflammation, synaptic plasticity in glutamatergic synapses and neurogenesis.
ADORA2A Liste de produits
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Informations sur les médicaments cliniques
| Nom anglais | Code de recherche | Phase de R&D | Entreprise | Indication | Essai clinique |
|---|---|---|---|---|---|
| Naproxen/Caffeine | BAY-2880376 | Phase 3 Clinical | Bayer AG | Pain, Postoperative | Details |
| Imaradenant | AZD-4635; HTL-1071 | Phase 2 Clinical | Nxera Pharma UK Ltd | Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Solid tumours | Details |
| Ciforadenant | CPI-444; V-81444 | Phase 2 Clinical | Vernalis (R&D) Ltd | Attention Deficit Disorder with Hyperactivity; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Multiple Myeloma; Neoplasms; Parkinson Disease | Details |
| Caffeinol | Phase 2 Clinical | Cardium Therapeutics | Alcoholic Intoxication; Alcoholism; Carcinoma, Non-Small-Cell Lung; Disruptive, Impulse Control, and Conduct Disorders; Ischemic Stroke | Details | |
| Etrumadenant | AB-928; GS-0928 | Phase 2 Clinical | Arcus Biosciences Inc | Breast Neoplasms; Carcinoma, Merkel Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Head and Neck Neoplasms; Hormone-Resistant Prostate Neoplasms; Hypopharyngeal Neoplasms; Laryngeal Neoplasms; Lung Neoplasms; Melanoma; Mouth Neoplasms; Neoplasm Metastasis; Oral Squamous Cell Carcinoma; Oropharyngeal Neoplasms; Oropharyngeal Squamous Cell Carcinoma (OPSCC); Ovarian Neoplasms; Pharyngeal Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms | Details |
| PORT-8 | PORT-8; TT-53 | Phase 2 Clinical | Tarus Therapeutics Inc | Solid tumours | Details |
| ND10(Theialife Inc) | ND-10; ND10 | Phase 2 Clinical | Theialife Inc | Cataract; Dry Eye Syndromes; Myopia | Details |
| PORT-6 | PORT-6; TT-10 | Phase 2 Clinical | Impetis Biosciences Ltd | Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colorectal Neoplasms; Endometrial Neoplasms; Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms, Castration-Resistant; Squamous Cell Carcinoma of Head and Neck | Details |
| MK-1088 | MK-1088 | Phase 2 Clinical | Merck Sharp & Dohme LLC | Solid tumours | Details |
| VG081821AC | VG081821AC; VG-081821AC | Phase 2 Clinical | Zhejiang Vimgreen Pharmaceuticals Ltd | Metabolic Dysfunction-Associated Steatotic Liver Disease; Parkinson Disease | Details |
| ILB-2109 | WTS-001; ILB-2109 | Phase 2 Clinical | Hangzhou Wutong Tree Pharmaceutical Co Ltd | Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Head and Neck Neoplasms; Hodgkin Disease; Melanoma; Nasopharyngeal Carcinoma; Neoplasms; Ovarian Neoplasms; Sarcoma; Solid tumours; Triple Negative Breast Neoplasms; Uterine Cervical Neoplasms | Details |
| PBF-999 | PBF-999 | Phase 1 Clinical | Palobiofarma Sl | Huntington Disease; Neoplasms | Details |
| [18F]MNI-444 | [18F]MNI-444 | Phase 1 Clinical | Invicro Llc | Diagnostic agents | Details |
| SHR-5126 | SHR-5126 | Phase 1 Clinical | Jiangsu Hengrui Medicine Co Ltd | Neoplasms | Details |
| Taminadenant | NIR-178; PBF-509 | Phase 1 Clinical | Palobiofarma Sl | Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Colorectal Neoplasms; Head and Neck Neoplasms; Lymphoma, Large B-Cell, Diffuse; Melanoma; Ovarian Neoplasms; Pancreatic Neoplasms; Parkinson Disease; Prostatic Neoplasms, Castration-Resistant; Solid tumours; Triple Negative Breast Neoplasms | Details |
| ST-4206 | ST-4206 | Phase 1 Clinical | Alfasigma Spa | Parkinson Disease | Details |
| CKD-512 | CKD-512 | Phase 1 Clinical | Chong Kun Dang Pharmaceutical Corp | Neoplasms; Solid tumours | Details |
| JNJ-86974680 | JNJ-86974680 | Phase 1 Clinical | Johnson & Johnson Enterprise Innovation Inc | Carcinoma, Non-Small-Cell Lung; Prostatic Neoplasms | Details |
| YZJ-5053 | YZJ5053; YZJ-5053 | Phase 1 Clinical | Shanghai Haiyan Pharmaceutical Technology Co Ltd | Neoplasm Metastasis; Solid tumours | Details |
| CT-1500 | CT-1500 | Phase 1 Clinical | Circadian Technologies Ltd | Details | |
| DZD-2269 | DZD-2269 | Phase 1 Clinical | Dizal Pharmaceutical Co Ltd | Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant | Details |
| INCB-106385 | INCB-106385 | Phase 1 Clinical | Incyte Corp | Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Colorectal Neoplasms; Gastrointestinal Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms, Castration-Resistant; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms | Details |
| CS-3005 | CS-3005 | Phase 1 Clinical | Cstone Pharmaceuticals (Suzhou) Co Ltd | Solid tumours | Details |
Informations sur les médicaments commercialisés
| Nom anglais | Code de recherche | Phase de R&D | Entreprise | Plus ancien nom de marque | Pays d'approbation le plus ancien | Indication la plus ancienne | Société d'approbation la plus ancienne | Date d'approbation la plus ancienne | Indication | Essai clinique |
|---|---|---|---|---|---|---|---|---|---|---|
| Regadenoson Hydrate | CVT-3146 | Approved | Astellas Pharma Inc | Rapiscan, 海诺生, Lexiscan | United States | Contrast agents | Astellas Pharma Inc | 2008-04-10 | Anemia, Sickle Cell; Astrocytoma; Cardiovascular contrast agents; Cardiovascular Diseases; Contrast agents; Coronary Artery Disease; Coronavirus Disease 2019 (COVID-19); Diagnostic agents; Glioblastoma; Glioma; Heart Diseases; Myocardial Ischemia; Oligodendroglioma; Pneumonia; Rejection of lung transplantation; Retinal Artery Occlusion | Details |
| Caffeine/Ergotamine Tartrate | Approved | Novartis Pharma Ag | Cafergot | Japan | Vascular Headaches; Migraine Disorders; Tension-Type Headache | Nichi-Iko Pharmaceutical Co Ltd | 1948-11-26 | Migraine Disorders; Tension-Type Headache; Vascular Headaches | Details | |
| Oxtriphylline | Approved | Theocolin | Canada | null | Asthma | Details | ||||
| Caffeine/Metamizole Sodium/Dihydroergotamine Mesylate | Approved | Cefaliv | Migraine Disorders | Details | ||||||
| Adenine | Approved | Leucon | Japan | Leukopenia | Ohara Pharmaceutical Co Ltd | Leukemia; Leukopenia | Details | |||
| Acetaminophen/Butalbital/Caffeine/Codeine Phosphate | Approved | Actavis Laboratories Ut Inc | United States | Headache; Headache Disorders | Actavis Laboratories Ut Inc | 1992-07-30 | Headache; Headache Disorders | Details | ||
| Istradefylline | KW-6002 | Approved | Kyowa Hakko Kirin Co Ltd | Nourianz, Nouriast | Japan | Parkinson Disease | Kyowa Hakko Kirin Co Ltd | 2013-03-25 | Amyotrophic Lateral Sclerosis; Cognition Disorders; Hepatic Insufficiency; Movement Disorders; Parkinson Disease; Restless Legs Syndrome; Sleep Wake Disorders; Substance-Related Disorders | Details |
| Sodium Citrate/Citric Acid/Dextrose/Monosodium phosphate/Adenine/Mannitol/Sodium Chloride | Approved | Details | ||||||||
| Sodium Citrate/Citric Acid/Dextrose | Approved | Details | ||||||||
| Sodium Citrate/Citric Acid/Dextrose/Monosodium phosphate/Adenine | Approved | Details | ||||||||
| Aspirin/Acetaminophen/Caffeine/Thiamine | Approved | Fever; Pain | Details | |||||||
| Propranolol hydrochloride/Caffeine/Phenytoin Sodium | Approved | Mainland China | Hebei Tiancheng Pharmaceutical Co Ltd | Details | ||||||
| Salicylamide/Acetaminophen/Caffeine | Approved | Arthralgia; Fever; Headache; Neuralgia; Rheumatic Diseases | Details | |||||||
| Compound Paracetamol Caffeine and Pseudoephedrine Hydrochloride | Approved | Common Cold | Details | |||||||
| Acetaminophen/Methylephedrine Hydrochloride/Dextromethorphan Hydrobromide/Chlorphenamine Maleate/Caffeine/Sulfogaiacol | Approved | Mainland China | Common Cold | Zhejiang Apeloa Kangyu Pharmaceutical Co Ltd | Common Cold | Details | ||||
| Dextromethorphan Hydrobromide/Chlorphenamine Maleate/Sodium Citrate/Ammonium Chloride/Caffeine | Approved | 尔可芬 | Cough | Details | ||||||
| Acetaminophen/Caffeine/Codeine Phosphate/Diphenhydramine Hydrochloride | Approved | 斯力帮 | Headache | Details | ||||||
| Ferric Ammonium Citrate/Vitamin B1/Sodium glycerophosphate/Caffeine | Approved | Ischemia | Details | |||||||
| Norethidranum Dipropionas/Caffeine/Vitamin B6 | Approved | Mainland China | Contraception | Huazhong Pharmaceutical Co Ltd | 1981-01-01 | Contraception | Details | |||
| Acetaminophen/Propyphenazone/Caffeine | Approved | 散利痛, 散列通 | Common Cold | Details | ||||||
| Quinine Hydrochloride Hydrate/Caffeine | Approved | Malaria | Details | |||||||
| Dihydroergocryptine/Caffeine | Approved | 洛斯宝, VASOBRAL | Diabetes Mellitus; Diabetic Retinopathy | Details | ||||||
| Aminophenazone/Phenacetin/Caffeine | Approved | Fever; Pain | Details | |||||||
| Aminophenazone/Caffeine/Calcium Glycerophosphate | Approved | Dysmenorrhea; Headache; Neuralgia | Details | |||||||
| Acetaminophen/Caffeine/Chlorphenamine Maleate | Approved | Common Cold | Details | |||||||
| Aminophenazone/Caffeine/Chlorphenamine Maleate | Approved | Common Cold; Headache; Neuralgia | Details | |||||||
| Aspirin/Caffeine/Codeine Phosphate | Approved | 柯克 | Pain | Details | ||||||
| Acetaminophen/Pseudoephedrine Hydrochloride/Caffeine | Approved | Common Cold | Details | |||||||
| Aspirin/Acetaminophen/Caffeine/Chlorphenamine Maleate | Approved | Common Cold | Details | |||||||
| Aspirin/Caffeine/Chlorphenamine Maleate/Tartaric Acid | Approved | Common Cold | Details | |||||||
| Acetaminophen/Caffeine/Pseudoephedrine Hydrochloride/Chlorphenamine Maleate | Approved | Common Cold | Details | |||||||
| Aminophenazone/Phenacetin/Caffeine/Phenobarbital | Approved | Migraine Disorders | Details | |||||||
| Acetaminophen/Chlorphenamine Maleate/Caffeine/Guaifenesin | Approved | Common Cold | Details | |||||||
| Acetaminophen/Amantadine Hydrochloride/Caffeine/Artificial Bezoar | Approved | Common Cold | Details | |||||||
| Acetaminophen/Salicylamide/Pseudoephedrine Hydrochloride/Caffeine/Triprolidine Hydrochloride Hydrate | Approved | 联邦菲迪乐 | Common Cold | Details | ||||||
| Sodium Benzoate/Caffeine | Approved | Central Nervous System Diseases | Details | |||||||
| Aminophenazone/Caffeine | Approved | Fever | Details | |||||||
| Antipyrine/Caffeine | Approved | Common Cold | Details | |||||||
| Aspirin/Caffeine | Approved | Common Cold | Details | |||||||
| Antipyrine/Caffeine/Citric Acid | Approved | 米格来宁 | Mainland China | Sedation | Mudanjiang Lingtai Medicdment Co Ltd, Xi'An Disai Biological Pharmaceutical Co Ltd, Heilongjiang Hasing Pharmaceutical Group Co Ltd, Huadong Medicine (Xi'An) Bodyguard Pharmaceutical Co Ltd | 1982-01-01 | Sedation | Details | ||
| Aminophenazone/Acetaminophen/Caffeine/Chlorphenamine Maleate | Approved | 克感敏, 扑感敏, 朴感敏 | Common Cold | Details | ||||||
| Acetaminophen/Caffeine/Ephedrine Hydrochloride/Diphenhydramine Hydrochloride | Approved | Influenza, Human | Details | |||||||
| Acetaminophen/Caffeine/Chlorphenamine Maleate/Artificial Bezoar | Approved | Common Cold | Details | |||||||
| Aspirin/Phenacetin/Caffeine | Approved | Arthralgia; Dysmenorrhea; Fever; Headache; Neuralgia; Toothache | Details | |||||||
| Aspirin/Caffeine/Acetaminophen | Approved | United States | Migraine Disorders | Haleon PLC | Anesthesia; Migraine Disorders | Details | ||||
| Acetaminophen/Butalbital/Caffeine | Approved | Headache | Details | |||||||
| Acetaminophen/Caffeine | Approved | Zentiva As | Mainland China | Pain | Sino--American Shanghai Squibb Pharmaceutical Ltd | Pain | Details | |||
| Sodium glycerophosphate/Caffeine/Vitamin B/Phosphoric Acid/Niacin | Approved | Details | ||||||||
| Acetaminophen/Caffeine/Phenylephrine Hydrochloride/Chlorphenamine Maleate/Vitamin B | Approved | Details | ||||||||
| Acetaminophen/Chlorphenamine Maleate/Methylephedrine Hydrochloride/Sulfogaiacol/Caffeine | Approved | Mainland China | Common Cold | Hainan Sanfengyou Pharmaceutical Co Ltd | 2006-05-16 | Common Cold | Details | |||
| Brompheniramine Maleate/Bromhexine Hydrochloride/Caffeine/Acetaminophen/Phenylephrine Hydrochloride | Approved | Common Cold | Details | |||||||
| Acetaminophen/Amantadine Hydrochloride/Caffeine/Chlorphenamine Maleate/Artificial Bezoar | Approved | 复方氨酚烷胺 | Mainland China | Common Cold | null | 1984-01-01 | Common Cold | Details | ||
| Caffeine | Approved | Apnea; Cocaine-Related Disorders; Cognitive Dysfunction; Consciousness; Delirium; Diabetes Complications; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Disorders of Excessive Somnolence; Fatigue; Fetal Membranes, Premature Rupture; Intermittent Claudication; Memory Disorders; Mental Fatigue; Parkinson Disease; Postoperative Cognitive Complications; Sexual Dysfunction, Physiological; Sleepiness; Spinal Cord Injuries | Details |